血清补体水平与原发性高血压及其危险因素的相关性分析

发布时间：2018-05-05 06:34

本文选题：补体 + 原发性高血压　；参考：《西安交通大学学报(医学版)》2017年05期

【摘要】：目的探讨血清补体C3、C4与原发性高血压及其危险因素同型半胱氨酸(HCY)和血脂的关系。方法选取20例健康体检者为对照组,45例高血压患者为高血压组。高血压组依据血脂异常防治指南又分为调脂组和未调脂组,分别测定各组血清补体C3、C4和HCY、总胆固醇、低密度脂蛋白、载脂蛋白等水平,并采用Pearson相关性分析补体与HCY及血脂指标的相关性。结果与对照组比较,高血压组的补体C3、C4显著升高,差异有统计学意义(P0.05),HCY亦显著升高(P0.05)。高血压组Pearson相关性分析显示,补体C3与总胆固醇、低密度脂蛋白、载脂蛋白B均呈正相关(P0.05);补体C3、C4与同型半胱氨酸无关(P=0.073,P=0.699)。与未调脂组比较,调脂组补体C4、总胆固醇、低密度脂蛋白、载脂蛋白B显著降低(P0.05)。调脂组Pearson相关性分析显示,补体C3、C4与低密度脂蛋白等血脂指标无关(P0.05);补体C3、C4与同型半胱氨酸无关(P=0.074,P=0.894)。结论补体C3、C4与原发性高血压密切相关;补体系统激活是高血压重要危险因素;调脂治疗明显减轻高血压患者的免疫损伤;高同型半胱氨酸血症(HHCY)是原发性高血压独立危险因素。
[Abstract]:Objective to investigate the relationship between serum complement C _ 3 C _ 4 and essential hypertension and its risk factor, homocysteine homocysteine (HCY) and blood lipids. Methods 20 healthy persons were selected as control group and 45 patients with hypertension as hypertension group. The hypertension group was divided into two groups according to the guidelines for the prevention and treatment of dyslipidemia. The serum levels of complement C _ 3C _ 4 and HCY, total cholesterol, low density lipoprotein and apolipoprotein were measured in each group. Pearson correlation was used to analyze the correlation between complement and HCY and blood lipid index. Results compared with the control group, the complement C _ 3C _ 4 in the hypertension group was significantly higher than that in the control group, and the difference was statistically significant (P 0.05). Pearson correlation analysis showed that complement C 3 was positively correlated with total cholesterol, low density lipoprotein and apolipoprotein B, while complement C 3 C 4 had no correlation with homocysteine. Compared with the control group, the complement C _ 4, total cholesterol, low density lipoprotein and apolipoprotein B decreased significantly in the lipid regulating group. The correlation analysis of Pearson showed that complement C _ 3C _ 4 had no relationship with lipid index such as low density lipoprotein (LDL-C), while complement C _ 3C _ 4 had no relationship with homocysteine (P = 0.074) or homocysteine (n = 0.894). Conclusion complement C _ 3C _ 4 is closely related to essential hypertension, activation of complement system is an important risk factor for hypertension, lipid regulation therapy can significantly reduce the immune damage in patients with hypertension, and hyperhomocysteinemia is an independent risk factor for essential hypertension.
【作者单位】：西安交通大学医院内科;西安交通大学第一附属医院心内科;
【基金】：西安市科技计划项目[No.SF09026(1)]~~
【分类号】：R544.11

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