左旋氨氯地平、替米沙坦及氢氯噻嗪同时或不同时给药对反杓型高血压的影响

发布时间：2018-05-05 13:51

本文选题：左旋氨氯地平 + 替米沙坦　；参考：《中国老年学杂志》2017年10期

【摘要】：目的探讨左旋氨氯地平、替米沙坦及氢氯噻嗪同时或不同时给药对反杓型高血压的影响。方法收缩压(SBP)180 mm Hg,舒张压(DBP)91~109 mm Hg,年龄45岁的反杓型高血压患者200例,随机分为不同时给药组:晨服替米沙坦40 mg、氢氯噻嗪10 mg,晚服左旋氨氯地平5 mg;同时给药组上述3种药物均晨服。治疗前及治疗后8 w行动态血压监测检查。结果治疗8 w后两组24 h SBP/DBP分别降低30.28/13.12 mm Hg和29.98/13.87 mm Hg,日间SBP/DBP分别降低24.26/10.39 mm Hg和26.69/12.24 mmg,夜间SBP/DBP分别降低37.50/17.71 mm Hg和32.94/15.41 mm Hg,均较治疗前明显下降(P0.05);治疗后两组24 h SBP/DBP相较无明显差异(P0.05),而治疗后不同时给药组日间SBP/DBP较同时给药组高(P0.05),夜间SBP/DBP较同时给药组低(P0.05)。不同时给药组的逆转率为61%,高于同时给药组的为31%(P0.05)。结论左旋氨氯地平、替米沙坦及氢氯噻嗪两种服药方法均能有效控制24 h血压,不同时给药能更好地逆转杓型血压。
[Abstract]:Objective to investigate the effects of levamlodipine, telmisartan and hydrochlorothiazide on antidipper hypertension. Methods 200 patients with antidipper hypertension aged 45 years were treated with SBP 180 mm Hg, DBP 91 ~ 109 mm Hg, systolic blood pressure (SBP) 180 mm, and diastolic hypertension (DBP) 91 ~ 109mm Hg, aged 45 years, in 200 patients with antidipper hypertension. They were randomly divided into three groups: telmisartan 40 mg, hydrochlorothiazide 10 mg and levamlodipine 5 mg in the morning. Ambulatory blood pressure monitoring was performed before treatment and 8 weeks after treatment. Results after 8 weeks of treatment, the SBP/DBP decreased 30.28% 13.12 mm Hg and 29.98% 13.87 mm Hg, the daytime SBP/DBP decreased 24.26% 10.39 mm Hg and 26.69% 12.24 mmg, the night SBP/DBP decreased 37.50% 17.71 mm Hg and 32.94% 15.41 mm Hg respectively, which were significantly lower than that before treatment (P 0.05). There was no significant difference (P 0.05), but the day SBP/DBP of different time administration group was higher than that of simultaneous administration group, and the SBP/DBP at night was lower than that of simultaneous administration group (P 0.05). The reversal rate of different administration group was 61%, which was higher than that of simultaneous administration group (31%) (P 0.05). Conclusion levamlodipine, telmisartan and hydrochlorothiazide can effectively control 24 h blood pressure, and dipper blood pressure can be reversed better at different time.
【作者单位】：哈励逊国际和平医院老年病一科;
【分类号】：R544.1

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