经导管肾交感神经射频消融术治疗顽固性高血压疗效及安全性的Meta分析

发布时间：2018-05-05 19:07

本文选题：顽固性高血压 + 经导管肾交感神经射频消融术　；参考：《中国老年学杂志》2017年18期

【摘要】：目的系统评价经导管肾交感神经射频消融术治疗顽固性高血压的疗效和安全性。方法检索Cochrane Library、PubMed、EM base、CNKI、VIP和万方等数据库,两名独立研究者按纳入排除标准选择文献、提取资料,采用Rev Man5.2软件进行数据处理和分析。结果纳入20篇文献,共2 294例患者。Meta分析结果显示:治疗组较对照组,术后第3、6个月收缩压及舒张压均明显降低,经导管肾交感神经射频消融术疗效优于单用药物治疗组(P0.01)。在自身对照研究中1 152例,患者治疗术后第3、6个月同样显示降压效果良好(P0.01)。手术无反应率较低,术后并发症较少。结论经导管肾交感神经射频消融术治疗顽固性高血压的疗效明显,安全性较高。但鉴于纳入研究质量不高,结论需更高质量、大样本的随机对照试验进一步证实。
[Abstract]:Objective to evaluate the efficacy and safety of transcatheter renal sympathetic nerve radiofrequency ablation in the treatment of refractory hypertension. Methods the databases of Cochrane Library PubMedus Cochrane and Wanfang were searched. According to the exclusion criteria, two independent researchers selected the literature and extracted the data. The data were processed and analyzed by Rev Man5.2 software. Results A total of 2 294 patients. Meta-analysis results showed that systolic and diastolic blood pressure in the treatment group was significantly lower than that in the control group at the 3rd and 6th month after operation. The therapeutic effect of radiofrequency catheter ablation of renal sympathetic nerve was better than that of the single drug therapy group (P 0.01). In an autocontrol study, 1 152 patients showed good antihypertensive effects at the 3rd and 6th month after treatment. No reaction rate was lower and postoperative complications were less. Conclusion Transcatheter renal sympathetic radiofrequency ablation is effective and safe in the treatment of refractory hypertension. But since the quality of inclusion study is not high, the conclusion needs higher quality, which is further confirmed by a large sample of randomized controlled trials.
【作者单位】：兰州大学第二医院心内3科;
【基金】：“十二五”国家科技支撑计划项目(No.2011BA11B01)
【分类号】：R544.1

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