apoB与LDL-C评估冠心病风险的临床价值比较

发布时间：2018-05-07 20:31

本文选题：载脂蛋白B + 低密度脂蛋白胆固醇　；参考：《南方医科大学学报》2017年07期

【摘要】：目的探讨在载脂蛋白B(apoB)与低密度脂蛋白胆固醇(LDL-C)含量不一致情况下,比较apoB与LDL-C对冠心病风险评估的重要价值。方法将接受冠脉造影检查的患者作为研究对象,共603例,根据apoB、LDL-C中位数水平分为低值组和高值组,然后两两组合,共分为4组(低apoB/低LDL-C组,低apoB/高LDL-C组,高apoB/低LDL-C组,高apoB/高LDL-C组),根据冠状动脉造影结果评估冠脉病变支数及冠状动脉狭窄程度,探讨apoB与LDL-C与冠心病及其病变严重程度之间的关系。结果比较4组冠心病血管病变支、冠脉病变程度,差异明显存在统计学意义(P0.05)。当LDL-C、apoB含量一致时,与低低组相比,高高组的冠脉病变支数及冠脉病变程度有统计学差异(P0.05)。当apoB与LDL-C含量不一致时,与低低组相比,高apoB低LDL-C组冠脉病变支数明显增多(P=0.017),冠脉病变严重(P=0.034);而低apoB高LDL-C组冠脉病变支数及严重程度差异不明显(P0.05)。采用Pearson相关性分析,LDL-C、apoB、均为冠心病的危险因子。比较LDL-C和apoB的ROC曲线下面积,LDL-C为0.579(P=0.014),而apoB为0.589(P=0.006)。结论在apoB与LDL-C不一致情况下,apoB与LDL-C均为冠心病的危险因子,与冠心病病变程度密切相关,且apoB与LDL-C相比,在预测冠心病风险上同样具有重要的指导意义。
[Abstract]:Objective to investigate the value of apoB and LDL-C in assessing the risk of coronary heart disease (CHD) in the absence of consistency between apolipoprotein B (apoB) and low density lipoprotein cholesterol (LDL-C). Methods 603 patients undergoing coronary angiography were divided into low value group and high value group according to the median level of apoB LDL-C. Then they were divided into 4 groups (low apoB/ low LDL-C group, low apoB/ high LDL-C group, high apoB/ low LDL-C group). According to the results of coronary angiography, the number of coronary artery lesions and the degree of coronary artery stenosis were evaluated, and the relationship between apoB and LDL-C and the severity of coronary heart disease and its pathological changes were investigated in the group of high apoB/ and high LDL-C. Results the degree of coronary artery disease in the four groups was significantly different (P 0.05). When the content of LDL-CtropoB was the same, there were significant differences in the number of coronary artery lesion branches and the severity of coronary artery lesion between the high group and the low group (P 0.05). When the contents of apoB and LDL-C were not consistent, the number of coronary lesion branches in high apoB low LDL-C group was significantly higher than that in low apoB low LDL-C group, and the coronary artery lesion was serious, but there was no significant difference in the number and severity of coronary artery lesion in low apoB and high LDL-C group (P 0.05). Pearson correlation analysis showed that LDL-Capo B was a risk factor for coronary heart disease. Compared with the ROC curve of LDL-C and apoB, the area under the ROC curve of LDL-C and apoB was 0.579P0. 014, and apoB was 0. 589 P0. 006. Conclusion both ApoB and LDL-C are risk factors of coronary heart disease when apoB and LDL-C are inconsistent, and apoB is also important in predicting the risk of coronary heart disease compared with LDL-C.
【作者单位】：南方医科大学南方医院惠侨医疗中心心血管病区;
【基金】：国家自然科学基金(81370380) 广东省教育厅省级重大项目(2014KZDXM020) 广州市科技计划科学研究专项一般项目(201510010090) 南方医科大学临床研究培育项目(LC2016PY002)~~
【分类号】：R541.4

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