血清sFas和sLOX-1与急性冠状动脉综合征发生及发展的相关性研究

发布时间：2018-05-08 01:17

本文选题：急性冠状动脉综合征 + 可溶性Fas　；参考：《重庆医学》2017年35期

【摘要】：目的探讨可溶性Fas(sFas)和可溶性凝集素样氧化低密度脂蛋白受体-1(sLOX-1)水平与急性冠状动脉综合征(ACS)发生、发展的相关性。方法选取经冠状动脉造影(CAG)确诊的ACS患者52例(ACS组),其中不稳定型心绞痛(UA)23例(UA组)、急性心肌梗死(AMI)29例(AMI组);另选取同期CAG证实冠状动脉无狭窄者58例作为对照组(NC组)。采用酶联免疫吸附试验测定血清sFas、sLOX-1水平。结果与NC组比较,ACS组患者血清sFas、sLOX-1水平升高(P0.01);UA组和AMI组患者血清sFas、sLOX-1水平均高于NC组,且AMI组患者血清sFas、sLOX-1水平高于UA组(均P0.01)。ACS患者血清sFas与sLOX-1水平呈明显正相关(r=0.825,P=0.001),但二者与肌酸激酶同工酶MB(CK-MB)、肌钙蛋白I(cTnI)无明显相关性(P0.05)。结论血清高水平sFas和sLOX-1可能是ACS的危险因素。
[Abstract]:Objective to investigate the relationship between the levels of soluble FasS Fas1 and soluble lectin-like oxidized low density lipoprotein receptor-1 and ACSs in patients with acute coronary syndrome (ACS). Methods Fifty-two patients with ACS diagnosed by coronary angiography (CAG), including 23 patients with unstable angina pectoris and 29 patients with acute myocardial infarction (AMI), were selected as control group, and 58 patients with CAG with no coronary artery stenosis were selected as control group. The serum levels of sFas-sLOX-1 were measured by enzyme linked immunosorbent assay (Elisa). Results compared with NC group, the serum levels of sFas-sLOX-1 in ACS group were higher than those in NC group. The serum levels of sFas-sLOX-1 in patients with AMI were significantly higher than those in patients with UA (the levels of sFas and sLOX-1 were positively correlated with those of patients with P0.01).ACS, but there was no significant correlation between them and creatine kinase isoenzyme MBCK-MBN, troponin I ~ (2 +) cTnI) (P0.055.The serum levels of sFas-sLOX-1 in patients with P0.01).ACS were significantly higher than those in patients with UA (P < 0.05). Conclusion the high serum levels of sFas and sLOX-1 may be risk factors for ACS.
【作者单位】：济南大学山东省医学科学院医学与生命科学学院;山东省医学科学院附属医院心内科;山东省医学科学院附属医院医务部;滨州医学院附属医院心内科;
【分类号】：R541.4

【相似文献】