幽门螺杆菌感染与冠心病关系的meta分析

发布时间：2018-05-09 05:18

  本文选题：幽门螺杆菌 + 冠心病　； 参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:探讨幽门螺杆菌(Helicobacter pylori)感染与冠心病的相关性。方法:检索相关文献,对符合纳入标准的文献进行资料提取,用Revman5.3软件进行meta分析,计算合并效应量OR值及对应的95%可信区间(95%CI),再绘制漏斗图评价发表性偏倚。结果:共纳入12篇文献,病例组和对照组共19935例。幽门螺杆菌感染与冠心病关系的合并OR值为1.24,95%CI:1.12-1.38,I~2=7%。按照随访时间不同,分为随访时间5年(OR=1.12,95%CI:0.93-1.35,I~2=0%)和随访时间≥5年(OR=1.23,95%CI:1.09-1.39,I2=48%),表明长期慢性感染幽门螺杆菌与冠心病有相关性,且幽门螺杆菌感染是冠心病的危险因素,倒漏斗图示基本对称。按研究人群不同,分为高危人群(OR=1.18,95%CI:1.04-1.34,I~2=0%)和一般人群(OR=1.44,95%CI:1.21-1.73,I~2=0%),表明幽门螺杆菌感染对冠心病的结局有影响。有3篇文献检测CagA+,其合并OR值为OR=0.94,95%CI:0.76-1.52,I~2=0%,表明CagA+与冠心病没有相关性。结论:幽门螺杆菌感染与冠心病有相关性。
[Abstract]:Objective: to investigate the correlation between Helicobacter pylori (HP) infection and coronary heart disease (CHD). Methods: the relevant literature was retrieved, and the data of the literature that met the inclusion criteria were extracted. The meta analysis was carried out with Revman5.3 software. The OR value of the combined effect and the 95% confidence interval (95% CI) were calculated, and then the funnel graph was drawn to evaluate the published bias. Results: totally 12 articles were included, 19935 cases in case group and control group. The combined OR value of the relationship between Helicobacter pylori infection and coronary heart disease was 1.24 + 95% CI: 1.12-1.38% I ~ 2 / 7. According to the time of follow up, it was divided into 5 years' follow up time: 1. 12 ~ 95% CI: 0.93-1. 35% I ~ (2 +) and 5 years' follow-up time 鈮，

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