血清CTRP5水平与原发性高血压患者早期肾损害的相关性研究

发布时间：2018-05-09 19:45

本文选题：高血压 + 早期肾损害　；参考：《河北医科大学》2017年硕士论文

【摘要】：目的:本课题通过检测原发性高血压(Essential Hypertension,EH)患者血清CTRP5水平,阐明血清CTRP5水平与高血压早期肾损害的相关性。方法:收集2016年1月到2016年12月就诊于河北医科大学第二医院门诊的原发性高血压患者96例,入选患者参照《中国高血压防治指南2010》的诊断标准:收缩压≥140mmHg和(或)舒张压≥90mmHg。根据患者尿微量白蛋白(mAlb)/尿肌酐(Cr)的比值(UACR)为依据,分为以下两组:1对照组,不合并早期肾损害[UACR30mg/g];2实验组,合并早期肾损害[UACR30-300mg/g]。测定所有入选者的CTRP5、同型半胱氨酸(Hcy)、血肌酐(SCr)、尿素氮(BUN)水平。比较两组间CTRP5、Hcy、SCr、BUN水平,以探讨CTRP5水平对于高血压早期肾损害的预测价值。结果:1与对照组相比,观察组CTRP5水平显著高于对照组,具有统计学差异。(138.92±21.76,105.06±13.70,P0.01)。2观察组Hcy水平显著高于对照组,具有统计学差异。(19.15±3.62,10.52±2.94,P0.01)。3 Pearson相关分析表明,CTRP5、Hcy与UACR呈正相关。r值分别为0.657、0.991,P均0.01。4多元线性回归分析表明:CTRP5、Hcy可能是影响UACR的独立危险因素,其回归系数B值分别是2.525(P0.01)、22.867(P0.01)。结论:观察组血清CTRP5水平升高,与UACR呈正相关。CTRP5可能是影响高血压患者UACR的独立危险因素之一。
[Abstract]:Objective: to clarify the correlation between serum CTRP5 level and early renal damage in patients with essential hypertension (Essential Hypertension, EH). Methods: to collect 96 cases of primary hypertension who were diagnosed at the second hospital of Hebei Medical University from January 2016 to December 2016. National guidelines for the prevention and treatment of hypertension 2010>: systolic pressure more than 140mmHg and (or) diastolic pressure more than 90mmHg. based on the ratio of urine microalbumin (mAlb) / creatinine (Cr) in patients with the ratio (UACR), divided into two groups: 1 control group, without early renal damage [UACR30mg/g]; 2 experimental group, combined with early renal damage [UACR30-300mg/g]. determination all entry CTRP5, homocysteine (Hcy), serum creatinine (SCr), urea nitrogen (BUN) level. Compare the levels of CTRP5, Hcy, SCr, BUN between the two groups in order to explore the predictive value of CTRP5 level for early renal damage in hypertension. Results: 1 compared with the control group, the CTRP5 level of the observation group was significantly higher than that of the control group, with a statistically significant difference (138.92 + 21.76105.06 + 13.70). The Hcy level in the.2 observation group was significantly higher than that in the control group, with a statistically significant difference. (19.15 + 3.62,10.52 + 2.94, P0.01).3 Pearson correlation analysis showed that CTRP5, Hcy and UACR were positively correlated with 0.657,0.991. Not 2.525 (P0.01), 22.867 (P0.01). Conclusion: the increase of serum CTRP5 level in the observation group and positive correlation with UACR may be one of the independent risk factors affecting UACR in hypertensive patients.

【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R544.1

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