平均血小板体积对经皮冠状动脉介入治疗患者发生主要不良心血管事件的预测价值

发布时间：2018-05-09 22:00

本文选题：冠状动脉疾病 + 经皮冠状动脉介入治疗　；参考：《山东医药》2017年01期

【摘要】：目的探讨平均血小板体积(MPV)对经皮冠状动脉介入(PCI)治疗患者术后主要不良心血管事件(MACE)的影响。方法选择冠状动脉造影明确诊断冠心病并行PCI治疗患者393例,根据有无发生MACE将患者分为MACE组25例和无MACE组368例,比较两组患者吸烟、高血压、糖尿病、血脂异常发生情况,分析MPV与MACE的关系。结果术后随访(24.5±6.5)月,与无MACE组患者比较,MACE组患者高血压、糖尿病发生率增高,MPV增大,差异有统计学意义(P均0.05)。多因素Cox回归分析显示在校正其他因素影响后,MPV是MACE的独立预测因素(RR=2.243,95%CI为1.686~3.172,P0.05)。受试者工作特征曲线显示MPV预测MACE的曲线下面积为0.715(95%CI为0.643~0.806,P0.05),最佳界点为10.52 fl,敏感度为0.548,特异度为0.782。结论 MPV是冠心病患者PCI术后发生MACE的独立预测因素,与患者不良预后相关。
[Abstract]:Objective to investigate the effect of mean platelet volume (MPV) on major adverse cardiovascular events (MACEs) after percutaneous coronary intervention (PCI). Methods 393 patients with coronary artery disease (CHD) and treated with PCI were divided into MACE group (n = 25) and no MACE group (n = 368) according to MACE. The incidence of smoking, hypertension, diabetes and dyslipidemia were compared between the two groups. The relationship between MPV and MACE was analyzed. Results the postoperative follow-up was 24.5 卤6.5 months. Compared with the patients without MACE, the incidence of diabetes in Mace group was significantly higher than that in Mace group (P < 0.05). Multivariate Cox regression analysis showed that MPV was an independent predictor of MACE after adjusting for other factors. The operating characteristic curve of the subjects showed that the area under the curve of MACE predicted by MPV was 0.715(95%CI 0.643 ~ 0.806 (P0.05), the best boundary point was 10.52 fls, the sensitivity was 0.548, and the specificity was 0.782. Conclusion MPV is an independent predictor of MACE after PCI in patients with coronary heart disease.
【作者单位】：柳州市人民医院;
【分类号】：R541.4

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