MPV联合hs-CRP、IL-6预测非再灌注急性心肌梗死患者发生MACE的临床价值

发布时间：2018-05-10 22:14

本文选题：非再灌注急性心肌梗死 + MPV　；参考：《新疆医科大学》2016年硕士论文

【摘要】：目的:评估MPV联合hs-CRP、IL-6预测非再灌注急性心肌梗死患者发生MACE的临床价值。方法:连续选入2014年10月至2015年10月就诊于新疆医科大学第一附属医院初发的急性心肌梗死患者150例,根据是否行PCI术,分为PCI组(再灌注治疗组)和非PCI组(非再灌注组),比较两组一般临床资料和实验室检查指标的差异。根据是否发生主要不良心血管事件(MACE),又将两组分别分为MACE组和非MACE组,进一步分析两亚组组内和组间MPV、hs-CRP、IL-6的差异,研究三指标与再灌注和非再灌注急性心肌梗死患者住院期间发生MACE相关性。计算MPV、hs-CRP、IL-6与三变量联合检测的ROC曲线下面积,评估它们在AMI预后中的预测价值。随访患者出院后1月内MACE发生率,比较MPV、hs-CRP、IL-6治疗前后变化情况。结果:PCI组与非PCI组比较,两组间在年龄、BMI、LVEF、MACE、MPV、hs-CRP、IL-6有统计学差异;在性别、民族、糖尿病病史、高血压病史、血糖、TC、LDL-C、HDL-C、CK、CK-MB、hs-cTnT、PLT、PDW、PCT等无统计学差异。MPV、hs-CRP、IL-6水平在两组组内和组间比较,差异有统计学意义。相关分析结果示:MPV和hs-CRP、IL-6呈中等正相关。三者联合检测的ROC曲线下面积最大。随访1月后,PCI组MACE发生率与非PCI组相比差异无统计学差异;三变量治疗前后无明显变化。结论:MPV联合hs-CRP、IL-6检测可提高非再灌注急性心肌梗死患者住院期间发生MACE的预测价值。
[Abstract]:Objective: to evaluate the clinical value of MPV combined with hs-CRP IL-6 in predicting MACE in patients with non-reperfusion acute myocardial infarction. Methods: one hundred and fifty consecutive patients with acute myocardial infarction were selected from October 2014 to October 2015 in the first affiliated Hospital of Xinjiang Medical University. According to whether they were treated with PCI or not, PCI group (reperfusion group) and non-reperfusion group (non-reperfusion group) were divided into two groups. According to the occurrence of major adverse cardiovascular events, the two groups were divided into two groups: MACE group and non MACE group. The differences of IL-6 between the two subgroups were analyzed. To study the correlation between three indexes and MACE during hospitalization in patients with reperfusion and non-reperfusion acute myocardial infarction. The area under the ROC curve of MPV hs-CRP IL-6 and three variables was calculated to evaluate their prognostic value in AMI. The incidence of MACE within 1 month after discharge was compared before and after treatment. Results there was significant difference between the two groups in age, nationality, history of diabetes, history of hypertension, blood glucose level of TCLDL-CnTPLTPLTP-PDWPCT. There was no significant difference between the two groups in the levels of MPVHs-CRPN6 in the two groups and between the two groups, and there was a significant difference in the levels of IL-6 between the two groups, and there was a significant difference between the two groups in the level of IL-6, and there was a significant difference between the two groups. The results of correlation analysis showed that there was a moderate positive correlation between the two groups. The area under the ROC curve detected by the three methods was the largest. After 1 month follow-up, the incidence of MACE in PCI group was not significantly different from that in non PCI group, and there was no significant change before and after treatment with three variables. Conclusion the detection of 7% MPV combined with hs-CRPU IL-6 can improve the predictive value of MACE during hospitalization in patients with non reperfusion acute myocardial infarction.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R542.22

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