H型高血压患者颈动脉结构和功能变化及与亚临床炎症的相关性

发布时间：2018-05-11 07:48

本文选题：H型高血压 + 颈动脉硬化　；参考：《南方医科大学学报》2012年08期

【摘要】：目的探讨H型高血压患者颈动脉结构与功能的变化,及其与亚临床炎症的相关性。方法选择H型高血压患者60例(A组),非H型高血压患者49例(B组),与在南方医科大学第三附属医院体检的健康者作为正常对照组20例(C组),对3组人群均行彩色超声检查;同时进行超敏C反应蛋白(hs-CRP)、纤维蛋白原(FIB)、肿瘤坏死因子-α(TNF-α)的水平进行测定,比较3组之间颈动脉超声参数及炎性标志物的水平,观察H型高血压患者颈动脉结构与功能的变化,及其与亚临床炎症的相关性。结果 H型高血压组与非H型高血压组比较,血压水平[收缩压(136.0±10.1)mmHg vs(131.9±7.0)mmHg,舒张压(80.9±8.9)mmHg vs(73.2±7.9)mmHg],差异无统计学意义(均P0.05)。颈动脉IMT[H型高血压组(1.52±0.08)mm vs非H型高血压组(1.09±0.06)mm]、扩张性[H型高血压组(0.23±0.14)mmHg-1×100 vs非H型高血压组(0.46±0.14)mmHg-1×100]、血清Hcy[H型高血压组(15.37±5.89)vs非H型高血压组(8.19±4.53)μmol/L],差异有统计学意义(均P0.05),H型高血压组血浆超敏C反应蛋白、纤维蛋白原、肿瘤坏死因子-α水平,均高于非H型高血压组,且与颈动脉结构与功能参数变化呈正相关。结论 H型高血压患者更易发生颈动脉结构与功能损害。亚临床炎症和H型高血压患者颈动脉结构与功能损害密切相关。H型高血压患者更易发生颈动脉结构与功能损害的机制,可能与亚临床炎症、高同型半胱氨酸血症对高血压的协同作用有关,应采取积极干预措施。
[Abstract]:Objective to investigate the changes of carotid artery structure and function in patients with type H hypertension and its correlation with subclinical inflammation. Methods 60 patients with type H hypertension (group A), 49 non H hypertensive patients (group B), and 20 healthy persons at the Third Affiliated Hospital of Southern Medical University as normal control group (group C), were treated with color for the 3 groups of people. Ultrasound examination; simultaneous determination of hypersensitive C reaction protein (hs-CRP), fibrinogen (FIB), tumor necrosis factor - alpha (TNF- alpha), comparison of the level of carotid artery ultrasound parameters and inflammatory markers between the 3 groups, observed changes in the structure and function of carotid artery in patients with H type hypertension, and the correlation with subclinical inflammation. Results H type Compared with non H hypertension group, blood pressure level [systolic pressure (136 + 10.1) mmHg vs (131.9 + 7) mmHg, diastolic pressure (80.9 + 8.9) mmHg vs (73.2 + 7.9) mmHg]), the difference was not statistically significant (P0.05). The carotid IMT[H hypertension group (1.52 + 0.08) mm vs non H type hypertension group (1.09 + 0.06), dilated hypertensive group (0.23 + 0.14) MHg-1 * 100 vs non H hypertension group (0.46 + 0.14) mmHg-1 x 100], serum Hcy[H type hypertension group (15.37 + 5.89) vs non H hypertension group (8.19 + 4.53) mu mol/L], the difference was statistically significant (all P0.05). The plasma hypersensitivity C reactive protein, fibrinogen and tumor necrosis factor - alpha level in the H hypertension group were higher than those in the non hypertensive hypertensive group. There is a positive correlation between the changes in the arterial structure and functional parameters. Conclusion the carotid structure and function damage is more likely to occur in patients with type H hypertension. The subclinical inflammation and the impairment of carotid artery structure and function in patients with type H hypertension are closely related to the mechanism of carotid artery structure and function damage in patients with type.H hypertension, which may be associated with subclinical inflammation. Hyperhomocysteinemia is related to the synergistic effect of hypertension. Active intervention should be taken.

【作者单位】：南方医科大学第三附属医院心内科;南方医科大学第三附属医院超声科;
【基金】：广东省医学科学技术研究基金(wstJJ20091118) 南方医科大学第三附属医院院长基金(B201011)
【分类号】：R544.1

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