辛伐他汀联合银杏叶片对心性猝死综合征患者的血脂及颈动脉粥样硬化斑块的影响

发布时间：2018-05-11 15:50

本文选题：辛伐他汀 + 银杏叶片　；参考：《中国临床药理学杂志》2017年13期

【摘要】：目的研究辛伐他汀联合银杏片对心性猝死综合征患者血脂及颈动脉粥样硬化斑块的影响。方法随机选取患者300例,将患者随机分为2组(每组150例):试验组(辛伐他汀20 mg+联合银杏叶片24 mg)与对照组(辛伐他汀20mg),每次1片,1日3次,疗程均为6个月。治疗后,用生化法检测患者的血脂水平;以颈动脉彩色多普勒超声测量斑块面积。结果在治疗6个月后,试验组和对照组的总胆固醇(TC)分别为(3.67±0.45),(4.21±0.24)mmol·L~(-1);三酰甘油(TG)分别为(1.44±0.47),(2.00±0.68)mmol·L~(-1);高密度脂蛋白胆固醇(HDL-C)分别为(0.98±0.12),(0.90±0.13)mmol·L~(-1);低密度脂蛋白胆固醇(LDL-C)分别为(1.84±0.41),(2.17±0.49)mmol·L~(-1)。与治疗前比较,2组差异均有统计学意义(均P0.05)。试验组的HDL-C水平显著高于对照组、而TC、TG、LDL-C水平低于对照组,差异均有统计学意义(均P0.05)。治疗前,试验组和对照组的斑块面积分别为(6.70±3.56),(6.38±3.68)mm~2。治疗后,试验组和对照组的斑块面积分别为(4.21±2.16),(4.77±2.70)mm~2。2组的斑块面积虽然减少,但与治疗前比较,差异无统计学意义(P0.05)。结论辛伐他汀联合银杏叶片对心性猝死综合征患者的TC、LDL-C、TG水平有降低作用并能够减少患者的斑块面积。
[Abstract]:Objective to study the effects of simvastatin combined with ginkgo biloba tablet on blood lipid and carotid atherosclerotic plaque in patients with sudden cardiac death syndrome. Methods 300 patients were randomly divided into two groups (150 cases in each group): the experimental group (simvastatin 20 mg combined with ginkgo biloba leaf 24 mg) and the control group (simvastatin 20 mg / day, 3 times a day for 6 months). After treatment, the blood lipid level was detected by biochemical method, and plaque area was measured by carotid color Doppler ultrasound. Results after 6 months of treatment, the total cholesterol levels in the test group and the control group were 3.67 卤0.45, 4.21 卤0.24)mmol, 1.44 卤0.47, 2.00 卤0.68)mmol, 0.98 卤0.12, 0.90 卤0.13)mmol, respectively, and 1.84 卤0.411 卤1.17 卤0.49)mmol, respectively, in the experimental group and control group. There were significant differences between the two groups before treatment (P 0.05). The level of HDL-C in the experimental group was significantly higher than that in the control group, while the level of TGG LDL-C in the test group was significantly lower than that in the control group (all P 0.05). Before treatment, the plaque area of the experimental group and the control group were 6.70 卤3.56g / kg and 6.38 卤3.68m / mm respectively. After treatment, the plaque area of the experimental group and the control group was 4.21 卤2.16 and 4.77 卤2.70)mm~2.2, respectively, although the plaque area decreased, but there was no significant difference between the two groups before and after treatment (P 0.05). Conclusion Simvastatin combined with Ginkgo biloba leaves can reduce the level of LDL-CTG in sudden cardiac death syndrome patients and reduce the plaque area of patients with sudden cardiac death syndrome.
【作者单位】：青海省红十字医院药学部;青海省心脑血管病专科医院干部保健科;
【基金】：青海省卫生计生科研基金资助项目(2016-wjqn-05)
【分类号】：R541.78

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