心血管疾病患者联合检测同型半胱氨酸及叶酸的临床意义

发布时间：2018-05-12 18:18

本文选题：心血管疾病 + Hcy　；参考：《广东医学》2017年15期

【摘要】：目的探讨血清同型半胱氨酸(Hcy)及叶酸的浓度与心血管疾病的关系。方法选取心血管疾病患者135例,分为心绞痛组、急性心肌梗死组及心肌炎组,每组45例,同时选取同龄的健康体检人群50例为对照组。血清Hcy的测定方法为循环酶法,叶酸的测定方法为化学发光法,并对结果进行分析。结果心绞痛组和急性心肌梗死组血清的Hcy水平比对照组高,而叶酸水平比对照组低,差异有统计学意义(P0.05)。心肌炎组血清Hcy及叶酸的水平与对照组差异无统计学意义(P0.05)。心绞痛组与急性心肌梗死组血清叶酸浓度随Hcy浓度的升高而出现降低,呈负相关(r=-0.653,r=-0.702,P0.05),而心肌炎组血清叶酸浓度与Hcy浓度无相关性(P0.05)。结论高血清Hcy浓度是心血管疾病的危险因素之一,在心血管疾病中,心绞痛和急性心肌梗死患者血清Hcy水平升高时,叶酸水平却出现了降低的情况,这说明了对此类心血管疾病高危人群应定期检测Hcy与叶酸水平,对低水平叶酸患者应通过及时补充叶酸等治疗措施,把Hcy水平控制在正常范围内,以降低此类心血管疾病的发生。
[Abstract]:Objective to investigate the relationship between serum homocysteine (Hcy) and folic acid concentration and cardiovascular disease. Methods 135 patients with cardiovascular disease were selected to be divided into angina pectoris group, acute myocardial infarction group and myocarditis group, 45 cases in each group, and 50 healthy people of the same age were selected as control group. Serum Hcy was determined by circulating enzyme method, folic acid. The Hcy level of serum in angina group and acute myocardial infarction group was higher than that of the control group, but the level of folic acid was lower than the control group (P0.05). The level of serum Hcy and folic acid in the myocarditis group was not statistically significant (P0.05). The angina group and the acute myocardial infarction group were not significantly different from those in the control group. Serum folic acid concentration in the patients with myocardial infarction decreased with the increase of Hcy concentration (r=-0.653, r=-0.702, P0.05), but there was no correlation between serum folate concentration and Hcy concentration in myocarditis group (P0.05). Conclusion high serum Hcy concentration is one of the risk factors of cardiovascular disease, in cardiovascular disease, angina and acute myocardial infarction When the level of serum Hcy is elevated, the level of folic acid decreases. This shows that the level of Hcy and folic acid should be regularly detected for the high risk population of such cardiovascular diseases. The level of Hcy in patients with low level folic acid should be controlled in the normal range by the timely supplementation of folic acid, in order to reduce the incidence of such cardiovascular diseases.

【作者单位】：广东药科大学附属门诊部检验科;广东医科大学附属医院检验科;
【分类号】：R446.1;R54

【相似文献】