稳心颗粒联合胺碘酮治疗冠心病心律失常的Meta分析

发布时间：2018-05-13 15:55

本文选题：稳心颗粒 + 胺碘酮　；参考：《中药新药与临床药理》2017年02期

【摘要】：目的系统评价稳心颗粒联合胺碘酮治疗冠心病心律失常的疗效及安全性。方法通过计算机以中文检索词:稳心颗粒、胺碘酮、冠心病心律失常,英文检索词:Wenxin Granules,Amiodarone,Coronary heart disease,Cardiac arrhythmia,检索中英文数据库,时间为建库至2016年11月,收集有关稳心颗粒联合胺碘酮(试验组)与单用胺碘酮(对照组)对比治疗冠心病心律失常的临床随机对照试验(RCT)。由2名评价员对纳入的研究进行资料提取和质量评价,并采用Rev Man 5.3软件进行统计学分析。结果纳入的23篇研究共2132例患者,分析结果显示:稳心颗粒联合胺碘酮组在临床总有效率[OR=4.79,95%(3.65,6.30),P0.00001],心电图改善率[OR=3.76,95%(1.95,7.26),P0.0001],临床症状缓解时间[SMD=-3.17,95%(-3.89.,-2.45),P0.00001],不良反应[OR=0.68,95%(0.49,0.94),P=0.02]与单用胺碘酮比较均有统计学意义,均优于单用胺碘酮组;在室性早搏[SMD=-5.05,95%(-10.11,0.01),P=0.05],房性早搏[SMD=-337.53,95%(-750.10,75.03),P=0.11]方面,与单用胺碘酮比较无统计学意义。结论在冠心病心律失常的治疗上,相比单用胺碘酮,稳心颗粒联合胺碘酮的临床疗效更加优越,并且安全性更高。
[Abstract]:Objective to evaluate the efficacy and safety of Wenxin granule combined with amiodarone in the treatment of coronary heart disease arrhythmia. Methods the Chinese key words: Wenxin granule, amiodarone, arrhythmia of coronary heart disease, and English word: Wenxin Granules-Amiodarone heart disease and cardiac heart disease were used to search the database in Chinese and English until November 2016. To collect the clinical randomized controlled trial of Wanxin granule combined with amiodarone (trial group) and amiodarone alone (control group) in the treatment of coronary heart disease arrhythmia. Data extraction and quality evaluation were carried out by two evaluators, and statistical analysis was carried out with Rev Man 5.3 software. Results 2132 patients were included in 23 studies. The results showed that the total effective rate of Wanxin granule combined with amiodarone group was 3.656.30g P 0.00001, the improvement rate of electrocardiogram was 1.957.26P0.0001, the time of remission of clinical symptoms [SMD-3.17995 -3.89.9- 2.45P0.00001], the adverse reaction [OR0.6890.94P0.02] was statistically significant compared with that of amiodarone alone. There was no significant difference in ventricular premature beats (SMD-5.05) and atrial premature beats (SMD-337.5395 + -750.100.1055.03P0. 11) in ventricular premature beats (SMD-5.05) and atrial premature beats (SMD-337.5395%). Conclusion compared with amiodarone alone, Wenxin granule combined with amiodarone is more effective and safe in the treatment of coronary heart disease arrhythmia.
【作者单位】：广州中医药大学第一附属医院;广东省第二中医院急诊科;广州中医药大学第一临床医学院;
【基金】：国家级大学生创新创业训练计划项目(201610572016)
【分类号】：R541.7

【相似文献】