绝经前后女性冠心病患者HDL及LDL颗粒与冠状动脉病变程度的相关性研究

发布时间：2018-05-15 01:38

本文选题：绝经前 + 绝经后　；参考：《中国动脉硬化杂志》2017年08期

【摘要】：目的探讨绝经前后女性冠心病患者高密度脂蛋白(HDL)颗粒及低密度脂蛋白(LDL)颗粒与冠状动脉病变程度的关系。方法收集经冠状动脉造影确诊的女性冠心病患者79例,根据是否绝经分为绝经前组(n=37)和绝经后组(n=42)。Lipoprint脂蛋白分析仪对HDL颗粒及LDL颗粒进行检测分析,探讨两种脂蛋白颗粒与冠状动脉病变程度的关系。结果与绝经前组比较,绝经后组大颗粒HDL浓度(102.6±45.2 mg/L比143.8±49.7 mg/L,P0.05)及所占比例(23.34%±8.26%比31.15%±7.98%,P0.05)、LDL颗粒平均直径(259.5±8.1姒比265.7±3.7姒,P0.05)均降低,小颗粒HDL浓度(124.0±76.8 mg/L比87.0±34.9 mg/L,P0.05)及所占比例(27.26%±12.34%比18.62%±6.53%,P0.05)、LDL B型比例(73.8%比48.6%,P0.05)、Gensini积分(50.88±26.46比30.43±18.54,P0.05)均增高。绝经前组及绝经后组多支病变患者大颗粒HDL浓度、LDL颗粒平均直径均低于单支病变患者,Gensini积分高于单支病变患者;绝经后组大颗粒HDL浓度、LDL颗粒平均直径均低于绝经前组,小颗粒HDL所占比例及Gensini积分高于绝经前组。绝经前组和绝经后组LDL颗粒大小及大颗粒HDL浓度均与Gensini积分呈负相关。结论与绝经前组相比,绝经后组大颗粒HDL浓度较低,小颗粒HDL浓度较高,LDL颗粒平均直径较小,冠状动脉病变程度较严重;大颗粒HDL浓度及LDL平均直径与冠状动脉病变严重程度明显相关。
[Abstract]:Objective to investigate the relationship between high density lipoprotein (HDL) granules and low density lipoprotein (LDL) granules and the severity of coronary artery disease in premenopausal and postmenopausal women with coronary heart disease. Methods 79 female patients with coronary heart disease diagnosed by coronary angiography were divided into premenopausal group and postmenopausal group according to whether they were divided into premenopausal group and postmenopausal group. The HDL granules and LDL granules were detected by Lipoprint lipoprotein analyzer. To investigate the relationship between two kinds of lipoprotein granules and the severity of coronary artery disease. Results compared with the premenopausal group, the HDL concentration of large particles in the postmenopausal group was 102.6 卤45.2 mg/L vs 143.8 卤49.7 mg / L P0.05), and the average diameter of the large particles was 23.34% 卤8.26% vs 31.15% 卤7.98% 卤7.98% 卤7.98 卤7.95 卤8.15 vs 265.7 卤3.7Si (P 0.05) in the postmenopausal group. The HDL concentration of small particles (124.0 卤76.8 mg/L vs 87.0 卤34.9 mg / L P0.05) and the ratio of 27.26% 卤12.34% to 18.62% 卤6.53% were higher than that of P0.05Gensini integral (50.88 卤26.46 vs 30.43 卤18.54 P0.05). In premenopausal and postmenopausal multivessel lesion patients, the mean diameter of large particle HDL particles was lower than that of single vessel lesion group, and the mean diameter of large particle HDL particles in postmenopausal group was lower than that in premenopausal group, and the mean diameter of large particle HDL in postmenopausal group was lower than that in premenopausal group. The proportion of HDL and Gensini score of small particles were higher than that of premenopausal group. The size of LDL particles and HDL concentration of large particles were negatively correlated with Gensini scores in premenopausal and postmenopausal groups. Conclusion compared with premenopausal group, postmenopausal group has lower HDL concentration, higher HDL concentration, smaller mean diameter and more severe coronary artery lesion. The concentration of HDL and the mean diameter of LDL were significantly correlated with the severity of coronary artery disease.
【作者单位】：山西医科大学;山西医科大学第二医院心内科心血管疾病诊治及临床药理山西省重点实验室;山西医科大学第一医院特需病房;山西医科大学第一医院心内科;
【分类号】：R541.4

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