慢性心力衰竭患者血清人附睾蛋白4表达及临床意义

发布时间：2018-05-15 17:40

  本文选题：人附睾蛋白 + 慢性心力衰竭　； 参考：《中国老年学杂志》2017年14期

【摘要】：目的通过检测慢性心力衰竭(CHF)患者血清人附睾蛋白(HE)4的水平,明确其与心力衰竭严重程度、N-端脑利钠肽前体(NTpro BNP)、肌酐的相关性。方法 CHF患者101例为CHF组,体检健康人群58例为对照组,采用酶联免疫吸附法测定血清HE4、NT-pro BNP的水平,并进行血生化指标检测。结果 CHF组HE4、NT-pro BNP水平较对照组显著升高(P0.05)。纽约心脏病协会(NYHA)心功能分级Ⅲ~Ⅳ级组、心功能分级Ⅰ~Ⅱ级组与对照组HE4及NT-pro BNP水平均具有统计学差异(P0.05)。HE4水平与NT-pro BNP、肌酐呈正相关。结论 CHF患者血清HE4的水平升高,HE4与心力衰竭的严重程度相关。HE4水平可能为CHF患者诊断及评估病情提供参考。
[Abstract]:Objective to detect the serum levels of human epididymal protein (HE4) in patients with chronic heart failure (CHF), and to determine the correlation between the level of Hep 4 and the severity of heart failure, NTpro BNPP and creatinine. Methods 101 patients with CHF were divided into CHF group and 58 healthy persons as control group. Serum HE4NT-pro BNP levels were measured by Elisa and blood biochemical indexes were detected. The results were as follows: (1) the level of NT-pro BNP in serum was determined by enzyme-linked immunosorbent assay (Elisa). Results the level of NT-pro BNP in CHF group was significantly higher than that in control group (P 0.05). New York Heart Association (NYHA) cardiac function grade 鈪，

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