复律宁颗粒联合西药治疗气阴两虚型慢性心力衰竭合并心律失常40例临床观察

发布时间：2018-05-16 21:11

本文选题：慢性心力衰竭 + 复律宁颗粒　；参考：《中医杂志》2017年21期

【摘要】：目的观察复律宁颗粒治疗气阴两虚型心力衰竭合并心律失常的疗效和安全性。方法将80例气阴两虚型心力衰竭合并心律失常患者分为治疗组和对照组各40例,对照组予心力衰竭合并心律失常的西医规范化治疗,治疗组在西医规范化治疗基础上加用复律宁颗粒,两组均治疗4周。比较两组患者治疗前后心功能分级、心脏超声指标[包括射血分数(EF)、每搏输出量(SV)、左心室舒张末期内径(LVEDD)]、B型脑钠肽(BNP)、6分钟步行试验、中医证候积分、明尼苏达心力衰竭生活质量调查表(MLHFQ)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分,评价两组心功能疗效及心律失常疗效。结果治疗后两组心功能疗效(治疗组总有效率80.00%,对照组为55.00%)及心律失常疗效(治疗组总有效率70.00%,对照组为42.50%)比较治疗组优于对照组(P0.05或P0.01)。两组治疗后中医证候积分、6分钟步行距离、MLHFQ积分、HAMA积分、HAMD积分均较治疗前明显改善,且治疗组优于对照组(P0.01)。两组治疗后BNP水平较治疗前均降低(P0.01),且两组间比较差异无统计学意义(P0.05)。两组治疗前后心脏超声各指标比较差异均无统计学意义(P0.05)。结论复律宁颗粒治疗气阴两虚型心力衰竭合并心律失常患者能有效改善心功能,减少患者的早搏发作,改善患者的临床症状和生活质量。
[Abstract]:Objective to observe the efficacy and safety of Fuyuning granule in treating heart failure complicated with arrhythmia of deficiency of qi and yin. Methods 80 patients with heart failure complicated with arrhythmia were divided into treatment group (n = 40) and control group (n = 40). The treatment group was treated with Fuluning granules on the basis of western standard treatment, and both groups were treated for 4 weeks. The cardiac function grading, echocardiographic parameters (including ejection fraction (EFF), ventricular output volume (SVN), left ventricular end-diastolic diameter (LVEDDD) were compared between the two groups before and after treatment. The effect of cardiac function and arrhythmia were evaluated by the Minnesota Heart failure quality of Life questionnaire (MLHFQN), Hamilton anxiety scale (Hamilton anxiety scale) and Hamilton Depression scale (Hamd). Results after treatment, the effect of cardiac function (the total effective rate was 80.00g in the treatment group and 55.00 in the control group) and arrhythmia (the total effective rate was 70.00in the treatment group and 42.50g in the control group) was better than that in the control group (P0.05 or P0.01). After treatment, the scores of TCM syndromes and 6 minutes walking distance and MLHFQ / Hama / Hamd were significantly improved in both groups, and the treatment group was superior to the control group (P 0.01). The level of BNP in the two groups was lower than that before treatment, and there was no significant difference between the two groups (P 0.05). There was no significant difference in echocardiographic parameters between the two groups before and after treatment (P 0.05). Conclusion Fuyuning granule can effectively improve cardiac function, reduce premature stroke and improve clinical symptoms and quality of life in patients with heart failure complicated with arrhythmia of deficiency of qi and yin.
【作者单位】：上海中医药大学附属龙华医院;大连市妇女儿童医疗中心;苏州市中医院;长兴县中医院;
【基金】：上海市卫生局中药新药及院内制剂研发项目(2011ZJ014) 上海市科学技术委员会科研计划(14401972501)
【分类号】：R541

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