双通道溶栓治疗急性下肢深静脉血栓形成的疗效分析

发布时间：2018-05-19 02:05

本文选题：急性下肢深静脉血栓形成 + 双通道　；参考：《重庆医科大学》2017年硕士论文

【摘要】：目的:探讨双通道连续给药治疗急性下肢深静脉血栓形成的临床疗效方法:回顾性分析我院收治的急性下肢深静脉血栓(DVT)128例患者的临床资料,根据给药途径分为双通道组(乆静脉鞘管+溶栓导管)60例,单通道组(溶栓导管)68例。分析两组溶栓治疗前后健患侧大腿周径差、小腿周径差、大腿消肿率、小腿消肿率、静脉通畅率、尿激酶总量、溶栓天数及并发症(出血率、肺栓塞发生率、导管相关性感染)。结果:溶栓治疗前两组的性别、年龄、患肢、血栓类型、髂静脉受压例数,以及健患侧大腿周径差、小腿周径差均未见明显差异(P0.05)。溶栓治疗后,双通道组的健患侧大腿周径差(1.22±0.62)明显小于单通道组(1.70±0.94),大腿消肿率(0.86±0.06)明显优于单通道组(P0.05),双通道组尿激酶用量(3.85×106U)、溶栓天数(6.5天)较单通道组尿激酶用量(4.85×106U)、溶栓天数(9天)明显减少(P0.05)。治疗前后健患侧小腿周径差及消肿率无差别(P0.05),治疗后两组患者静脉通畅率及并发症的发生率无明显差异(P0.05)。结论:两种途径治疗急性下肢深静脉血栓形成临床效果确切,双通道组较单通道组溶栓药物用量少、溶栓时间短、临床症状改善明显,值得在临床上应用。
[Abstract]:Objective: to investigate the clinical efficacy of double channel continuous administration in the treatment of acute deep venous thrombosis of lower extremity. Methods: the clinical data of 128 patients with DVT of acute deep venous thrombosis of lower extremity treated in our hospital were analyzed retrospectively. According to the way of administration, the patients were divided into two channels group (60 patients with thrombolytic catheter in the vein sheath tube and 68 patients with thrombolytic catheter with single channel group). The difference of thigh diameter, leg diameter, thigh swelling rate, lower leg swelling rate, venous patency rate, urokinase amount, thrombolytic days and complications (bleeding rate, pulmonary embolism rate, catheter-related infection) were analyzed before and after thrombolytic therapy. Results: before thrombolytic therapy, there were no significant differences in sex, age, limb, thrombus type, number of cases of iliac vein compression, thigh diameter difference and leg circumference difference between the two groups. After thrombolysis, The thigh circumference difference of the two channel group (1.22 卤0.62) was significantly lower than that of the single channel group (1.70 卤0.94), and the thigh swelling rate was 0.86 卤0.06), which was significantly better than that of the single channel group (P 0.05). The dosage of urokinase in the double channel group was 3.85 脳 10 6 UU, the days of thrombolysis was 6.5 days) and the number of days of thrombolytic thrombolysis was 4.85 脳 10 6 U (P < 0.05). P0. 05% decreased significantly (P 0. 05%, P 0. 05%). Before and after treatment, there was no difference in the difference of the diameter of the leg and the rate of detumescence between the two groups (P 0.05), but there was no significant difference in the rate of venous patency and the incidence of complications between the two groups after treatment. Conclusion: the two approaches are effective in the treatment of acute deep vein thrombosis of lower extremity. The dosage of thrombolytic drugs in the double channel group is less than that in the single channel group, the duration of thrombolysis is shorter, and the clinical symptoms are obviously improved, which is worthy of clinical application.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R543.6

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