MPO联合Hcy评估急性冠脉综合征患者病变程度的临床价值

发布时间：2018-05-19 16:06

本文选题：急性冠脉综合征 + 髓过氧化物酶　；参考：《中国地方病防治杂志》2017年08期

【摘要】：目的研究髓过氧化物酶(MPO)联合同型半胱氨酸(Hcy)评估急性冠脉综合征(ACS)患者病变程度的临床价值。方法选2015年5月-2017年2月我院98例冠心病患者作为研究对象,其中急性冠脉综合征患者50例作为ACS组,稳定型心绞痛患者48例作为SAP组,另选同期健康体检者49例作为对照组,对比3组基本信息[血糖、肌酐、高密度脂蛋白(HDL-C)、血清总胆固醇(TC)、甘油三酯(TG)、高血压占比、尿素氮(BUN)]及血浆MPO、Hcy水平,均行冠状动脉造影(ICA)检查,并分析血浆MPO、Hcy水平与冠状动脉病变支数及冠状动脉狭窄程度积分(Gensini)的相关性。结果ACS组血浆MPO、Hcy水平高于SAP组、对照组,三支血管病变患者血浆Hcy水平高于单支、两支血管病变者,Gensini积分≥30分患者血浆MPO、Hcy水平高于Gensini积分30分患者,差异有统计学意义(P0.05);Spearman相关分析可知,血浆MPO水平与病变支数无明显相关性(P0.05),与Gensini积分呈正相关(P0.05);血浆Hcy水平与病变支数、Gensini积分呈正相关(P0.05)。结论 ACS患者血浆MPO、Hcy水平异常升高,两者联合检测可反映动脉病变支数、狭窄程度,对评估ACS病变程度具有重要价值。
[Abstract]:Objective to study the clinical value of myeloperoxidase (MPO) combined with homocysteine (Hcy) in assessing the degree of pathological changes in patients with acute coronary syndrome (ACS). Methods 98 patients with coronary heart disease in our hospital in February, May 2015, were selected as research subjects, including 50 patients with acute coronary syndrome as ACS group and 48 patients with stable angina pectoris as group SAP. In the same period, 49 healthy subjects were selected as the control group. The basic information [blood sugar, creatinine, high density lipoprotein (HDL-C), serum total cholesterol (TC), triglyceride (TG), hypertension ratio, urea nitrogen (BUN)] and plasma MPO, Hcy level were compared, and the coronary angiography (ICA) examination was performed, and the plasma MPO, Hcy and coronary artery disease count were analyzed. Results the correlation of the degree score of coronary stenosis (Gensini). Results the plasma MPO, Hcy level in group ACS was higher than that in group SAP, and in the control group, the plasma Hcy level was higher than that of the single branch, and the plasma MPO of the patients with two vascular lesions, Gensini integral more than 30 points were higher than that of the Gensini integral (P0.05); the difference was statistically significant (P0.05); Spearma was statistically significant (P0.05); N correlation analysis showed that there was no significant correlation between plasma MPO level and the number of lesions (P0.05) and positive correlation with the Gensini score (P0.05); the plasma Hcy level was positively correlated with the number of pathological changes and the Gensini score (P0.05). Conclusion the plasma MPO, Hcy level in patients with ACS is abnormal, and the combination of the two tests can reflect the number of arterial lesions, the degree of stenosis, and the assessment of the ACS disease. The degree of change is of great value.
【作者单位】：邢台市人民医院心脏内科;河北医科大学第三医院外科;
【分类号】：R541.4

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