β3肾上腺素受体减轻持续房颤心房结构重构及收缩功能降低

发布时间：2018-05-21 06:28

本文选题：β受体抑制剂 + 持续房颤　；参考：《基因组学与应用生物学》2017年04期

【摘要】：为了研究β3肾上腺素受体在持续房颤心房重构中的作用,本研究选择实验犬21只,随机分为假手术组(n=7)、房颤组(n=7)和抑制剂组(n=7)。无菌条件下开胸后在犬右心耳缝植螺旋型起搏电极,连接实验用埋藏式高频起搏器(起搏模式AOO,600次/min),同时抑制剂组犬埋置持续给药泵,假手术组犬仅缝植起搏电极但不起搏,另2组犬心房快速起搏4周。分别于起搏前、起博4周后,检测记录各组犬房颤诱发情况;测量各组犬LAVmax、LAVmin和LAEF;测定左心耳LAAVmax,LAAVmin和LAAEF。我们发现起搏4周后,与假手术组相比,房颤组犬LAVmax、LAVmin、LAAVmax和LAAVmin均显著增加(p0.01),LAEF和LAAEF均明显下降(p0.01)。抑制剂组犬LAVmax、LAVmin、LAAVmax和LAAVmin均较房颤组有所降低(p0.01),而LAEF(p0.01)和LAAEF增加(p0.05)。假手术组和抑制剂组两组间比较可见显著差异。结果表明β3受体抑制剂能够减轻心房快速起搏犬心房结构重构和收缩功能降低,有益于防治房颤的心房结构重构。
[Abstract]:To study the role of 尾 3 adrenoceptor in atrial remodeling in patients with persistent atrial fibrillation, 21 dogs were randomly divided into sham-operated group (n = 7), atrial fibrillation group (n = 7) and inhibitor group (n = 7). Helical pacing electrodes were implanted into the right atrial auricle suture after sterility. The implanted high frequency pacemakers (AOO / 600 / min) were used to connect the experiment, while the continuous infusion pump was embedded in the inhibitor group, while in the sham operation group, the implanted pacing electrodes were only sewn but not pacing. The other two groups underwent rapid atrial pacing for 4 weeks. Atrial fibrillation was recorded before pacing and 4 weeks after pacing, LAVmax LAVmin and LAEFmin were measured, LAAVmaxlav LAAVmin and LAAEF in left atrial appendage (LAAVmax-LAAVmin) and LAAEF (LAAEF) were measured. We found that after 4 weeks of pacing, both LAVmaxLAVmin LAAVmax and LAAVmin increased significantly in atrial fibrillation dogs compared with sham operation group. Both LAEF and LAAEF were significantly decreased in AF group compared with sham-operated group. Compared with AF group, LAVmaxl LAVmin LAAVmax and LAAVmin in the inhibitor group were lower than that in AF group, while LAEFG p0.01) and LAAEF increased p0.05. There were significant differences between the sham operation group and the inhibitor group. The results showed that 尾 _ 3 receptor inhibitor could reduce atrial structural remodeling and contraction function in canine atrial rapid pacing, which was beneficial to the prevention and treatment of atrial structural remodeling in atrial fibrillation.
【作者单位】：齐齐哈尔医学院第三附属医院心内二科;
【基金】：齐齐哈尔市社会发展公关项目(SFGG-201518)资助
【分类号】：R541.75

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