还原型谷胱甘肽预防糖尿病患者冠状动脉造影术后对比剂肾病的临床研究

发布时间：2018-05-21 10:22

  本文选题：还原性谷胱甘肽 + 糖尿病　； 参考：《临床心血管病杂志》2017年12期

【摘要】：目的:探讨还原型谷胱甘肽对糖尿病患者冠状动脉造影术后对比剂肾病(CIN)的预防作用。方法:选取我院2015-01-2016-06收治的糖尿病且拟行冠状动脉造影术和(或)经皮冠状动脉介入术(PCI)的患者90例,采用前瞻性临床对照研究的方法随机分组为治疗组(44例)和对照组(46例)。治疗组给予还原型谷胱甘肽联合水化治疗,对照组仅给予水化治疗,比较2组术前及术后72h肾功能指标(血肌酐、血胱抑素C、肾小球滤过率)及CIN的发病率。结果:(1)术后72h,治疗组患者血肌酐和血胱抑素水平显著低于对照组[(89.5±18.4)μmol/L∶(99.5±20.4)μmol/L,P=0.016;(0.93±0.25)mg/L∶(1.18±0.33)mg/L,P=0.000 1],而肾小球滤过率则显著高于对照组[(92.5±22.5)ml·min-1·1.73m~(-2)∶(82.7±23.5)ml·min-1·1.73m~(-2),P=0.045];(2)本研究中共9例患者诊断为CIN,总体发病率为10%。其中治疗组和对照组CIN的发病率分别为2.33%和17.39%,差异有统计学意义(χ2=4.155,P=0.042)。结论:糖尿病患者行PCI诊疗后有较高的CIN发生风险,而应用还原型谷胱甘肽联合水化疗法可一定程度上降低糖尿病患者发生CIN的风险。
[Abstract]:Objective: to investigate the preventive effect of reduced glutathione on diabetic nephropathy after coronary angiography. Methods: ninety patients with diabetes mellitus undergoing coronary angiography and / or percutaneous coronary intervention were randomly divided into treatment group (n = 44) and control group (n = 46). The treatment group was treated with reduced glutathione combined with hydration, while the control group was only treated with hydration. The renal function indexes (serum creatinine, cystatin C, glomerular filtration rate) and the incidence of CIN were compared between the two groups before and 72 hours after operation. 缁撴灉:(1)鏈�鍚�72h,娌荤枟缁勬偅鑰呰��鑲岄厫鍜岃��鑳辨姂绱犳按骞虫樉钁椾綆浜庡�圭収缁刐(89.5卤18.4)渭mol/L鈭，

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