CYP4F2基因多态性与冠心病的相关性

发布时间：2018-05-22 18:02

本文选题：冠心病 + CYPF基因　；参考：《中国老年学杂志》2017年15期

【摘要】：目的研究CYP4F2基因多态性与冠心病(CAD)的相关性。方法对285例汉族CAD患者(冠心病组)和264例非CAD患者(对照组)进行问卷调查,采用高温连接酶检测反应技术进行基因扩增和基因分型,分析CYP4F2基因的2个单核苷酸多态性位点rs1558139和rs2108622多态性与CAD的相关性。结果 CAD组吸烟史和体重指数(BMI)均显著高于对照组(P0.05),高密度脂蛋白胆固醇(HDL-C)CAD组显著低于对照组(P=0.000),CAD组男性患者比例明显高于女性(P=0.001);CAD组CYP4F2基因rs1558139的基因型频率和等位基因频率与对照组无显著差异(P0.05),rs2108622的CC基因型频率在CAD组和对照组间差异显著(P0.05)。结论 CAD患者的危险因素是男性、有吸烟史、高BMI;CYP4F2基因rs1558139多态性与CAD无明显相关性,CYP4F2基因rs2108622多态性与CAD相关,携带CC基因型的患者发生CAD的风险增加。
[Abstract]:Objective to study the association between CYP4F2 gene polymorphism and coronary artery disease (CAD). Methods A total of 285 CAD patients (coronary heart disease group) and 264 non-CAD patients (control group) in Han nationality were investigated by questionnaire. The gene amplification and genotyping were performed by high temperature ligase assay. The relationship between rs1558139 and rs2108622 polymorphism and CAD in two single nucleotide polymorphisms (SNP) of CYP4F2 gene was analyzed. Results the smoking history and body mass index (BMI) in CAD group were significantly higher than those in control group (P 0.05), and the proportion of male patients with HDL-CU CAD group was significantly lower than that in control group P0. 000 CYP4F2 gene rs1558139 genotype frequency and allele were significantly higher in CAD group than in female group. There was no significant difference in CC genotype frequency between CAD group and control group. Conclusion the risk factors of CAD patients are male, smoking history. There is no significant correlation between the rs1558139 polymorphism of CYP4F2 gene and CAD in patients with CAD. The rs2108622 polymorphism of CYP4F2 gene is associated with CAD, and the risk of CAD in patients with CC genotype is increased.
【作者单位】：内蒙古自治区人民医院心内科;内蒙古医科大学附属医院核医学科;
【基金】：内蒙古自治区自然科学基金面上项目(2013MS1154)
【分类号】：R541.4

【相似文献】