腺苷酸活化蛋白激酶与心肌缺血再灌注损伤的研究进展

发布时间：2018-05-23 13:53

本文选题：心肌缺血再灌注损伤 + 腺苷酸活化蛋白激酶　；参考：《山东医药》2017年17期

【摘要】：腺苷酸活化蛋白激酶(AMPK)作为心肌细胞的能量感受器,其不仅能调节并感知心肌细胞内的能量状态,还能在心肌细胞缺血、缺氧条件下被激活,通过抑制ATP的消耗代谢途径,刺激ATP的生成代谢途径,维持心肌细胞的能量稳态,减少能量供应不足对心肌产生的损伤。此外,激活的AMPK还能通过抑制内质网应激、抑制细胞凋亡、优化能量代谢、调节自噬等作用减少缺血-再灌注过程中心肌细胞的损害面积,从而延长心肌细胞的存活率。
[Abstract]:Adenylate activated protein kinase (AMPK), as an energy receptor of cardiomyocytes, not only regulates and perceives the energy state in cardiomyocytes, but also can be activated during myocardial ischemia and hypoxia by inhibiting the pathway of ATP consumption and metabolism. Stimulating the metabolic pathway of ATP, maintaining the energy homeostasis of myocardial cells and reducing the damage caused by insufficient energy supply. In addition, activated AMPK can inhibit endoplasmic reticulum stress, inhibit cell apoptosis, optimize energy metabolism, regulate autophagy and reduce the area of myocardial cell damage during ischemia-reperfusion, thus prolonging the survival rate of cardiomyocytes.
【作者单位】：遵义医学院附属医院;
【基金】：国家自然科学基金项目(81360035、81560058) 贵州省科技攻关重点项目(黔科合SZ字2014-3022号) 贵州省教育厅自然科学招标项目(黔教科合KY字2013-165号)
【分类号】：R54

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