阿托伐他汀钙联合硝苯地平缓释片治疗老年高血压合并心律失常的疗效及对肝肾功能影响

发布时间：2018-05-23 16:25

本文选题：轻中度高血压 + 快速性心律失常　；参考：《中国地方病防治杂志》2017年03期

【摘要】：目的评估阿托伐他汀钙联合硝苯地平缓释片治疗老年轻中度高血压合并快速性心律失常的临床疗效及其对肝肾功能的影响。方法 138例患者分为2组,对照组给予硝苯地平缓释片治疗,治疗组在此基础上加用阿托伐他汀钙治疗。治疗18个月后,复查Holter心电图,观察心律失常情况,复查肝肾功能相关指标,血压控制情况。结果与治疗前相比,2组收缩压、舒张压均显著下降,但治疗组低于对照组,组间和组内差异有统计学意义(P0.05);2组房性早搏、室性早搏及房颤发生率均较治疗前降低,但治疗组低于对照组,组间和组内差异有统计学意义(P0.05);治疗组2例转氨酶升高。结论两种药物治疗老年高血压疗效更优,且无明显肝肾损害。
[Abstract]:Objective to evaluate the clinical effect of Atto vastatin calcium combined with nifedipine sustained-release tablets on elderly patients with mild to moderate hypertension complicated with tachyarrhythmia and its effect on liver and kidney function. Methods 138 patients were divided into two groups, the control group was treated with nifedipine sustained release tablet, and the treatment group was treated with Atto vastatin calcium. After 18 months of treatment, Holter electrocardiogram was reexamined, arrhythmia was observed, liver and kidney function indexes and blood pressure control were reexamined. Results compared with before treatment, systolic and diastolic blood pressure decreased significantly in both groups, but were lower in the treatment group than in the control group. There were significant differences in atrial premature beats, ventricular premature beats and atrial fibrillation between the two groups (P 0.05), and the incidence of ventricular premature beats and atrial fibrillation were lower than those before treatment. However, the treatment group was lower than the control group, and the difference between the two groups was statistically significant (P 0.05), while in the treatment group, the level of transaminase was increased in 2 cases. Conclusion the two drugs are more effective in the treatment of elderly hypertension, and there is no obvious damage of liver and kidney.
【作者单位】：衡水市哈励逊国际和平医院;
【基金】：河北省衡水市科技局科研基金立项项目(编号:14004A)
【分类号】：R541.7;R544.1

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