长期有氧运动对老年男性原发性高血压患者外周血单核细胞Toll样受体4的影响

发布时间：2018-05-24 19:52

本文选题：有氧运动 + 原发性高血压　；参考：《中国老年学杂志》2017年18期

【摘要】：目的观察16 w有氧运动对老年男性原发性高血压患者血液动力学、血浆肿瘤坏死因子(TNF)-α含量以及外周血单核细胞Toll样受体(TLR)4表达的影响。方法 60例老年男性原发性高血压患者按主观意愿分为运动组(E组)和对照组(C组)。E组进行16 w有氧运动,C组保持日常生活习惯不变。分别于试验前后测定心率和血压ELISA法测定血浆TNF-α含量,流式细胞术检测外周血单核细胞TLR4表达(阳性率)水平。结果与试验前比较,试验后E组安静心率和血压降低(P0.01),血浆TNF-α含量下降(P0.01),外周血单核细胞TLR4表达(阳性率)下调(P0.01);C组各指标均无显著性变化(P0.05)。试验后与C组比较,E组上述各指标均显著性降低(P0.01)。结论长期有氧运动可降低老年男性原发性高血压患者血压水平,其机制可能与抑制TLR4信号通路并下调炎症因子表达有关。
[Abstract]:Objective to observe the effects of aerobic exercise on hemodynamics, plasma tumor necrosis factor TNF- 伪 and the expression of Toll like receptor (TLR4) in peripheral blood monocytes in elderly male patients with essential hypertension at 16 weeks. Methods 60 elderly male patients with essential hypertension were divided into exercise group (group E) and control group (group C) according to their subjective wishes. The levels of TNF- 伪 in plasma and TLR4 expression in peripheral blood monocytes were measured by flow cytometry before and after the experiment. The blood pressure and heart rate were measured by ELISA method. The positive rate of TNF- 伪 in peripheral blood monocytes was detected by flow cytometry. Results compared with those before the experiment, the resting heart rate and blood pressure in group E decreased P0.01A, the content of TNF- 伪 in plasma decreased P0.01a, and the positive rate of TLR4 expression in peripheral blood monocytes decreased. There was no significant change in all indexes of group C (P0.01C). Compared with group C, the above indexes in group E were significantly lower than those in group C (P 0.01). Conclusion Long-term aerobic exercise can reduce the blood pressure level in elderly male patients with essential hypertension, and its mechanism may be related to the inhibition of TLR4 signaling pathway and down-regulation of inflammatory factor expression.
【作者单位】：吉林大学体育学院;吉林大学附属中学;
【基金】：国家哲学社会科学规划办公室社会科学基金资助课题(14BTY086)
【分类号】：G804.2;R544.11

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