哈萨克族原发性高血压患者血清胆红素及血脂水平的分析

发布时间：2018-05-25 02:29

本文选题：原发性高血压 + 哈萨克族　；参考：《东南大学学报(医学版)》2017年02期

【摘要】：目的:研究哈萨克族原发性高血压(EH)患者血清胆红素与血压、血脂的关系,并探讨胆红素水平的性别差异。方法:选取2014年11月至2015年4月接受流行病学调查的新疆哈萨克族人群267人作为研究对象,根据血压分为EH组(128例)和血压正常组(139例),对比分析各组总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),计算体重指数(BMI);另外根据性别将两组人群各分为两个亚组,对比分析各组血清胆红素水平。结果:与正常组比较,EH组TBIL、DBIL均较低(P0.05),年龄、BMI、TC、LDL-C均较高(P0.05)。各亚组组间比较,EH组女性较正常组女性TBIL、DBIL、IBIL均降低(P0.05),较EH组男性,TBIL、DBIL均降低(P0.05)。相关分析显示TBIL、DBIL与LDL-C呈负相关(r分别为-0.176、-0.233,P均0.05),DBIL与TC呈负相关(r=-0.192,P0.05)。结论:新疆哈萨克族EH患者的血清胆红素水平降低,BMI、TC、LDL-C升高;血清总胆红素及直接胆红素与血压有一定的相关性,并可能是哈萨克族女性患EH的危险因素;血清TBIL、DBIL可能是通过影响血脂代谢而影响血压的。
[Abstract]:Objective: to study the relationship between serum bilirubin and blood pressure and blood lipid in Kazakh patients with essential hypertension (EH) and to explore the gender difference of bilirubin level. Methods: from November 2014 to April 2015, 267 Kazak people in Xinjiang were selected as the subjects. According to blood pressure, there were 128 cases of EH group (n = 128) and 139 cases of normal blood pressure group (n = 139). The total bilirubin, direct bilirubin, indirect bilirubin, triglyceride, total cholesterol, low density lipoprotein cholesterol, high density lipoprotein gallbladder were compared and analyzed. The steroids were used to calculate the body mass index (BMI), and the two groups were divided into two subgroups according to their sex. The serum bilirubin level in each group was compared and analyzed. Results: compared with the normal group, the levels of TBILN DBIL in EH group were lower than those in the control group (P 0.05), and the LDL-C levels of TCU in the age group were higher than those in the control group (P 0.05). Compared with the normal control group, the levels of TBILDBILIBIL in EH group were lower than those in EH group, and that in EH group was lower than that in EH group. The correlation analysis showed that there was a negative correlation between LDL-C and LDL-C, r = -0.176 ~ -0.233N, P = 0.05 and TC, respectively. There was a negative correlation between DBIL and TC (r = -0.192, P < 0.05). Conclusion: the serum bilirubin level of Kazak EH patients in Xinjiang is lower than that of BMI-TCU LDL-C, and serum total bilirubin and direct bilirubin are correlated with blood pressure, and may be the risk factors of EH in Kazakh women. Serum TBILDBIL may affect blood pressure by affecting blood lipid metabolism.
【作者单位】：石河子大学医学院;石河子大学医学院第一附属医院;
【基金】：国家自然科学基金资助项目(81460075)
【分类号】：R544.11

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