阿托伐他汀联合曲美他嗪对老年冠心病左心功能不全患者心功能、炎性因子和血管内皮功能的影响

发布时间：2018-05-25 03:05

  本文选题：阿托伐他汀 + 曲美他嗪　； 参考：《中国老年学杂志》2017年20期

【摘要】：目的探讨阿托伐他汀联合曲美他嗪对老年冠心病左心功能不全患者心功能、炎性因子和血管内皮功能的影响。方法选取148例老年冠心病左心功能不全患者分为对照组及治疗组,对照组采用曲美他嗪治疗,治疗组在对照组基础上联合采用阿托伐他汀治疗,比较两组左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室后壁厚度(LVPWd)、纽约心脏病协会(NYHA)心功能分级、炎性因子和内皮细胞功能。结果治疗后两组LVEF均显著升高,LVEDD和LVPWd显著降低(P0.05)。治疗组炎性因子的降低程度明显高于对照组(P0.05),治疗组内皮细胞功能改善情况明显好于对照组(P0.05),在NYHA心功能分级方面,治疗组Ⅰ+Ⅱ级患者比例明显高于对照组(P0.05)。结论老年冠心病左心功能不全患者采用阿托伐他汀联合曲美他嗪可降低炎性因子水平改善心功能及血管内皮功能。
[Abstract]:Objective to investigate the effects of Atto vastatin combined with trimetazidine on left ventricular function, inflammatory factors and vascular endothelial function in elderly patients with coronary heart disease. Methods 148 elderly patients with left ventricular dysfunction were divided into control group and treatment group. The control group was treated with trimetazidine, and the treatment group was treated with Atto vastatin on the basis of control group. Left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDDD), left ventricular posterior wall thickness (LVPWD), NYHA (New York Heart Association) were compared between the two groups. Results after treatment, LVEF significantly increased and LVPWd decreased significantly in both groups (P 0.05). The decrease of inflammatory factors in the treatment group was significantly higher than that in the control group (P 0.05), and the improvement of endothelial cell function in the treatment group was significantly better than that in the control group (P 0.05). In terms of NYHA cardiac function classification, the proportion of patients of grade 鈪，

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