诊室、随诊间、24小时动态收缩压与老年人颈动脉内膜中层厚度的相关性

发布时间：2018-05-25 20:56

本文选题：收缩压 + 颈动脉内膜中层厚度　；参考：《华北理工大学》2017年硕士论文

【摘要】：目的探究在老年人群中诊室、随诊间、24小时动态收缩压(systolic blood pressure,SBP)与颈动脉内膜中层厚度(carotid intima-media thickness,CIMT)的相关性。方法开滦集团在2006-2007年度开展了包括在职和离退休职工的第一次健康体检,此后每两年进行一次体检,填写调查问卷并收集相关体检数据,并在2010-2011年度体检时随机抽取在开滦总医院、开滦林西医院、开滦赵各庄医院体检中的部分退休职工2814例,另外选择时间行诊室血压测量、24小时动态血压监测、颈动脉彩超等检查,符合纳入和排除标准的为2464例,最终资料完整的1423例纳入统计分析。按照诊室、随诊间、24小时、日间、夜间SBP的三分位数分别将研究对象分为三组,采用方差分析比较组间CIMT的平均值;采用Pearson相关和偏相关分析诊室、随诊间、24h、日间、夜间SBP与CIMT的关联;采用共线性诊断检验变量间共线性问题,并用逐步线性回归分别和同时分析上述SBP对CIMT的影响。结果1 1423例研究人群(男性、女性分别为940例、483例)的平均年龄为67.11±5.85岁,CIMT的平均值为0.92±0.18mm。2按照不同SBP三分位数分别将研究对象分为三组,CIMT随不同SBP水平升高呈增加趋势(P0.001)。3Pearson相关及偏相关分析显示诊室、随诊间、24小时、日间、夜间SBP与CIMT的相关系数在0.152~0.219之间(P0.001)。4校正影响因素后的逐步回归分析显示:上述SBP分别与CIMT呈线性相关,随着各SBP增加10mm Hg,对应的CIMT分别增加0.013mm、0.022mm、0.023mm、0.022mm、0.019mm(P均0.001)。去除共线性最大的24h SBP后,同时分析不同SBP对CIMT影响大小,结果显示随诊间和日间SBP与CIMT呈线性相关,β分别为0.151、0.104。结论1诊室、随诊间、24h、日间、夜间SBP与CIMT均存在关联。2随诊间和日间SBP与CIMT的关联优于诊室SBP,且随诊间SBP优于日间SBP。
[Abstract]:Objective to investigate the relationship between systolic blood pressure (SBP) and carotid intima-media thickness (IMT) in elderly patients. Methods Kailuan Group carried out the first physical examination in 2006-2007, which included in-service and retired workers, and every two years thereafter, completed the questionnaire and collected the relevant physical data. At the time of physical examination in 2010-2011, 2814 retired workers were randomly selected from Kailuan General Hospital, Kailuan Linxi Hospital and Kailuan Zhaogezhuang Hospital. In addition, 24 hours ambulatory blood pressure monitoring was performed in the clinic. According to the criteria of inclusion and exclusion, 2464 cases were examined by carotid color ultrasound, and 1423 cases with complete data were included in the statistical analysis. According to the three-digit number of SBP in the clinic, 24 hours follow-up room, daytime and night, the subjects were divided into three groups. The mean value of CIMT was compared by ANOVA, the Pearson correlation and partial correlation analysis were used, the follow-up interval was 24 hours, the day interval was 24 hours, and the mean value of CIMT in each group was compared by ANOVA. The correlation between SBP and CIMT at night and collinear diagnosis were used to test the collinearity problem between variables. The influence of SBP on CIMT was analyzed separately and simultaneously by stepwise linear regression. Results 1 1423 subjects (male, male) were included in the study. The average age of 67.11 卤5.85 years old was 0.92 卤0.18mm.2. The subjects were divided into three groups according to the three digits of different SBP. The three groups were divided into three groups with the increase of SBP level (P 0.001). 3 Pearson correlation analysis and partial correlation analysis showed that the patients were in the clinic, and the results were as follows: (1) the average age of the women was 67.11 卤5.85 years old, and the mean age was 0.92 卤0.92 卤0.92 卤0.92 卤0.92 卤0.92% respectively. The stepwise regression analysis showed that the correlation coefficient between SBP and CIMT was 0.152 卤0.219 in daytime and 0.152 卤0.219 in night, respectively. The stepwise regression analysis showed that the above SBP was linearly correlated with CIMT, and the CIMT increased by 0.013 mm / 0.022 mm / 0. 022 mm / 0. 019 mm / h respectively (P = 0. 001) with the increase of SBP. After removing the maximum co-linear SBP for 24 hours, the influence of different SBP on CIMT was analyzed. The results showed that SBP was linearly correlated with CIMT (尾 = 0.151) and CIMT (尾 = 0.104). Conclusion (1) in the diagnosis room, there was a correlation between SBP and CIMT at night and between SBP and CIMT in daytime, and the SBP in follow-up room was better than that in SBP in day. 2. The relationship between SBP and CIMT in night and in night was better than that in SBP in clinic. The SBP in follow-up room was better than that in SBP in day.
【学位授予单位】：华北理工大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R544.1

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