高血压合并冠心病患者血压变异性及其与靶器官损害的关系

发布时间：2018-05-25 21:47

本文选题：高血压 + 冠心病　；参考：《中国老年学杂志》2017年14期

【摘要】：目的探讨高血压合并冠心病(CHD)患者的血压变异性(BPV)及其与靶器官损害之间的关系。方法高血压患者201例根据冠状动脉造影结果分为高血压合并冠心病组(EH+CHD组)及单纯高血压组(EH组)。行24 h动态血压监测测定收缩压、舒张压标准差、变异系数评估血压变异性。心脏超声心动图检查计算左室质量指数(LVMI)。对两组患者相关临床资料、24 h动态血压变异性、LVMI、颈动脉内膜中层厚度(IMT)及24 h尿蛋白进行分析比较。结果与EH组相比,EH+CHD组患者24 h收缩压标准差和变异系数、24 h舒张压标准差和变异系数、白昼收缩压及夜间收缩压的标准差和变异系数及夜间舒张压变异系数均明显增高(P0.05)。白昼舒张压标准差和变异系数及夜间舒张压标准差两组无差异(P0.05)。EH+CHD患者24 h尿蛋白,颈动脉内膜中层厚度(IMT)均高于高血压组(P0.05)。但LVMI两组之间无差异(P0.05)。结论高血压合并CHD患者与单纯高血压患者相比,有更大的BPV,靶器官损害更重。
[Abstract]:Objective to investigate the relationship between BPVs and target organ damage in patients with hypertension complicated with coronary heart disease (CHD). Methods according to the results of coronary angiography, 201 patients with hypertension were divided into EH CHD group and EH group. Systolic blood pressure (SBP), diastolic blood pressure (DBP) standard deviation (DBP) were measured after 24 h ambulatory blood pressure monitoring. Left ventricular mass index (LVMI) was calculated by echocardiography. The clinical data of 24 h ambulatory blood pressure variability (24 h ambulatory blood pressure variability), carotid intima-media thickness (IMT) and 24 h urine protein were analyzed and compared between the two groups. Results compared with the EH group, the 24 h systolic blood pressure standard deviation and variation coefficient of EH CHD group were significantly higher than that of the 24 h diastolic blood pressure standard deviation and coefficient of variation, the daytime systolic blood pressure and night systolic blood pressure standard deviation and variation coefficient and the night diastolic pressure variation coefficient were significantly higher than that of the EH group (P 0.05). There was no difference in diurnal diastolic blood pressure standard deviation, variation coefficient and night diastolic blood pressure standard deviation between the two groups. 24 h urine protein and carotid intima-media thickness in patients with EH CHD were significantly higher than those in hypertension group (P 0.05). But there was no difference between the two groups in LVMI (P 0.05). Conclusion compared with simple hypertension patients, hypertension patients with CHD have greater BPVs and more serious damage to target organs.
【作者单位】：兰州大学第一医院心内科;
【基金】：甘肃省自然科学基金项目(1308RJZA228)
【分类号】：R541.4;R544.1

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