二甲双胍片联合替米沙坦治疗肥胖型高血压伴糖耐量减低患者效果观察

发布时间：2018-05-26 09:44

本文选题：高血压 + 二甲双胍　；参考：《山东医药》2017年26期

【摘要】：目的观察二甲双胍联合替米沙坦治疗肥胖型高血压伴糖耐量减低的临床疗效。方法将92例肥胖型高血压伴糖耐量减低患者随机分为观察组和对照组各46例,两组均给予对症治疗及替米沙坦片口服治疗,观察组加用二甲双胍片口服治疗。分别于治疗前、治疗第12周观察临床降压效果,取静脉血检测两组空腹血糖(FBG)、餐后2 h血糖(2 h BG)、空腹胰岛素(FINS)、餐后2 h胰岛素(2 h INS),计算胰岛素敏感性指数(ISI)、胰岛素抵抗指数(HOMA-IR)、BMI,记录不良反应。结果观察组临床降压总有效率76.09%,高于对照组的41.30%(P0.05);两组治疗后FBG、2 h BG、FINS、2 h INS、HOMA-IR、BMI均降低而ISI升高,且观察组较对照组更显著(P均0.05);两组治疗期间未出现严重不良反应。结论二甲双胍联合替米沙坦治疗肥胖型高血压伴糖耐量减低患者,不仅有助于降压,还可降低BMI、血糖并改善胰岛素敏感性,且安全性较好。
[Abstract]:Objective to observe the efficacy of metformin combined with telmisartan in the treatment of obese hypertension with impaired glucose tolerance. Methods 92 patients with obesity hypertension with impaired glucose tolerance were randomly divided into two groups: the observation group (n = 46) and the control group (n = 46). Both groups were given symptomatic treatment and telmisartan tablets orally, while the observation group were treated with metformin tablets orally. Before and after 12 weeks of treatment, the clinical hypotensive effect was observed. Fasting blood glucose (FBGG), fasting insulin (FINSN), insulin (2 h) and insulin (2 h) were measured in the two groups. The insulin sensitivity index (ISI) and insulin resistance index (HOMA-IRI) were calculated, and adverse reactions were recorded. Results the total effective rate of clinical hypotension in the observation group was 76.09, which was higher than that in the control group (41.30g / kg, P 0.05), and that in the two groups was lower than that in the control group at 2 h after treatment, and the ISI of the observation group was significantly higher than that of the control group (P < 0.05), and there was no serious adverse reaction in the two groups during the treatment period. Conclusion Metformin combined with telmisartan in the treatment of obese hypertensive patients with impaired glucose tolerance can not only help to reduce blood pressure, but also reduce BMI, blood sugar and improve insulin sensitivity, and the safety is good.
【作者单位】：贵州医科大学;贵州电力医院;
【分类号】：R544.1

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