老年高血压患者与老年高血压合并糖尿病患者颈动脉粥样硬化相关性研究

发布时间：2018-05-26 22:37

本文选题：老年高血压 + 糖尿病　；参考：《昆明医科大学》2015年硕士论文

【摘要】：目的：分析单纯老年原发性高血压与老年原发性高血压合并糖尿病两类患者并发颈动脉粥样硬化及粥样硬化斑块回声强度的差异,评估此差异对指导颈动脉粥样硬化的早期预防、疗效评估及预后的临床意义。方法：选取老年原发性高血压患者共161例,年龄65-95岁,男性87例,女性74例。所有纳入患者按照是否患有糖尿病分为2组,A组：老年高血压伴有糖尿病患者43例,其中37例伴颈动脉粥样硬化斑块的形成；B组：单纯老年高血压组118例,其中108例伴颈动脉粥样硬化斑块的形成。分别采集两组患者的性别、年龄、患高血压年限、体重指数、平均静息心率、动态血压、昼夜节律、肝肾功能、空腹血糖、血脂、颈动脉超声、颈动脉粥样硬化斑块回声强度等资料进行比较,并分析两组患者颈动脉粥样硬化斑块回声强度的影响因素。结果：①两组患者一般资料比较结果,差异均无统计学意义(P0.05)；②两组患者比较,颈动脉粥样硬化的形成,差异无统计学意义(P0.05)；③两组患者比较,A组患者颈动脉粥样硬化斑块回声强度低于B组患者,差异有统计学意义(P0.01)；④两组患者比较,A组患者空腹血糖较B组患者高,高密度脂蛋白胆固醇较B组患者低,差异有统计学意义(P0.01)；⑤患者性别与动脉粥样硬化硬斑、软斑的形成有相关性,差异有统计学意义(P0.05);结论：1.老年高血压合并糖尿病患者颈动脉粥样硬化斑块回声强度较低,相对不稳定。2.颈动脉粥样硬化的形成在单纯老年高血压和老年高血压合并糖尿病两组患者间无明显差异。3.颈动脉粥样硬化斑块的回声强度与血糖升高、高密度脂蛋白胆固醇降低有关。4.男性患者比女性患者更容易形成软斑。
[Abstract]:Objective: to analyze the difference of echo intensity of carotid atherosclerosis and atherosclerotic plaque between elderly essential hypertension and elderly essential hypertension with diabetes mellitus. To evaluate the clinical significance of this difference in early prevention, therapeutic evaluation and prognosis of carotid atherosclerosis. Methods: 161 elderly patients with essential hypertension, aged 65-95 years, 87 males and 74 females were selected. All patients were divided into two groups according to whether or not they had diabetes: 43 elderly patients with hypertension accompanied by diabetes, 37 patients with carotid atherosclerotic plaque formation, 118 patients with simple elderly hypertension, 108 cases of carotid atherosclerotic plaque formation. Sex, age, duration of hypertension, body mass index, mean resting heart rate, ambulatory blood pressure, circadian rhythm, liver and kidney function, fasting blood glucose, blood lipid, carotid ultrasound were collected. The echo intensity of carotid atherosclerotic plaque was compared and the influencing factors of echo intensity of carotid atherosclerotic plaque in two groups were analyzed. Results there was no significant difference in general data between the two groups. There was no significant difference in the formation of carotid atherosclerosis between the two groups. The echo intensity of carotid atherosclerotic plaque in group A was lower than that in group B, and there was significant difference between group A and group B, and the fasting blood glucose in group A was higher than that in group B. High density lipoprotein cholesterol (HDL-C) was lower in group B than that in group B (P 0.01). There was a significant correlation between sex and atherosclerotic hard spot and soft plaque formation in group B, and the difference was statistically significant (P 0.05). The echo intensity of carotid atherosclerotic plaques in elderly patients with hypertension and diabetes mellitus is low, relatively unstable. 2. 2. There was no significant difference in carotid atherosclerosis between the elderly hypertension group and the elderly hypertension with diabetes group. 3. 3. The echo intensity of carotid atherosclerotic plaques is associated with increased blood glucose and decreased high density lipoprotein cholesterol. Men are more likely to develop soft spots than women.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R544.1;R587.1

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