西尼地平片治疗原发性高血压的临床研究

发布时间：2018-05-27 23:21

  本文选题：西尼地平 + 交感神经兴奋性　； 参考：《中国临床药理学杂志》2017年17期

【摘要】：目的观察西尼地平片治疗原发性高血压的临床疗效及安全性。方法80例原发性高血压患者在服用西尼地平之前,每天早晨起床后(每天的同一时间)在家测量血压和心率,连续测量3 d并且记录,作为基线值。服用西尼地平后每2,4,8周复诊并记录血压和心率,疗程8周。比较基线值与西尼地平治疗后血压、心率的变化。结果治疗前、治疗2,4,8周后,诊室收缩压分别为(171.94±21.02),(148.19±11.28),(127.20±7.28),(126.98±7.52)mm Hg;舒张压分别为(97.91±15.27),(86.44±9.76),(77.85±6.87),(76.10±6.61)mm Hg;诊室心率分别为(76.31±9.72),(72.26±7.28),(70.01±6.22),(69.91±6.11)次/分;家庭收缩压分别为(170.13±18.98),(148.37±10.57),(127.52±7.30),(127.00±7.44)mm Hg,家庭舒张压分别为(97.20±12.59),(86.65±9.26),(77.95±6.63),(77.58±6.42)mm Hg;家庭心率分别为(76.05±9.17),(72.15±7.05),(69.98±6.15),(69.88±6.04)次/分;西尼地平治疗原发性高血压的有效率为88.89%(64/72例),差异均有统计学意义(均P0.05)。治疗过程中,头晕2例、低血压1例、面部潮红1例、潮热1例、心悸1例,药物不良反应发生率为7.5%(6/80例)。结论西尼地平可以有效降低原发性高血压患者的血压和心率。
[Abstract]:Objective to observe the efficacy and safety of cilnidipine tablets in the treatment of essential hypertension. Methods the blood pressure and heart rate of 80 patients with essential hypertension were measured at home after getting up every morning (at the same time every day) before taking cilnidipine for 3 days and recorded as the baseline value. Blood pressure and heart rate were recorded 8 weeks after taking cilnidipine for 8 weeks. To compare the baseline value with the changes of blood pressure and heart rate after treatment with cilnidipine. 缁撴灉娌荤枟鍓，

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