普伐他汀改善2型糖尿病合并高血压患者颈动脉粥样硬化研究

发布时间：2018-05-28 22:35

本文选题：普伐他汀 + 糖尿病　；参考：《重庆医学》2017年35期

【摘要】：目的探讨普伐他汀对2型糖尿病合并高血压患者颈动脉粥样硬化的影响。方法选取2015年4月至2016年4月该院收治的2型糖尿病合并高血压患者106例,将其分为常规治疗组(52例)和普伐他汀组(54例);常规治疗组患者给予控制饮食、降血糖、控制血压及对症支持治疗等常规治疗,普伐他汀组患者在常规治疗的基础上加用普伐他汀;治疗前后应用高频超声检测技术检测颈动脉内膜中层厚度(IMT),记录斑块检出率、颈动脉斑块积分的变化,同时检测血清血脂和高敏C反应蛋白(hsCRP)的变化。结果常规治疗组患者上述各项指标在治疗前后比较,差异无统计学意义(P0.05);普伐他汀组患者治疗后IMT值、斑块积分、斑块检出率均较治疗前降低,血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇及hs-CRP水平亦较治疗前降低,差异均有统计学意义(P0.05),并且治疗后普伐他汀组上述各项指标均明显低于常规治疗组(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论普伐他汀可以有效而安全地改善2型糖尿病合并高血压患者颈动脉粥样硬化程度。
[Abstract]:Objective to investigate the effect of pravastatin on carotid atherosclerosis in patients with type 2 diabetes mellitus and hypertension. Methods from April 2015 to April 2016, 106 patients with type 2 diabetes mellitus complicated with hypertension were divided into routine treatment group (n = 52) and pravastatin group (n = 54). Patients in pravastatin group were treated with pravastatin on the basis of routine treatment, IMTT was detected by high-frequency ultrasound before and after treatment, and plaque detection rate was recorded. Carotid plaque score, serum lipids and Gao Min C reactive protein hsCRP were measured. Results there was no significant difference in the above indexes before and after treatment in the routine treatment group (P 0.05), the IMT, plaque score, plaque detection rate of pravastatin group were lower than those before and after treatment, the serum total cholesterol and triglyceride were lower than those before and after treatment. The levels of low density lipoprotein cholesterol (LDL-C) and hs-CRP were significantly lower in pravastatin group than those before treatment (P 0.05), and the above indexes in pravastatin group were significantly lower than those in routine treatment group (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion Pravastatin can effectively and safely improve the degree of carotid atherosclerosis in patients with type 2 diabetes mellitus and hypertension.
【作者单位】：成都市第七人民医院内分泌代谢科;成都市第七人民医院肾内科;成都市第七人民医院神经内科;成都市第七人民医院医保科;
【基金】：四川省卫生厅科研项目(110057)
【分类号】：R544.1;R587.2

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