一氧化氮相关的巯基亚硝基化修饰及其对血管功能的调控

发布时间：2018-05-29 08:57

本文选题：一氧化氮 + 巯基亚硝基化　；参考：《生理学报》2017年05期

【摘要】：一氧化氮(nitric oxide,NO)作为重要的血管舒张活性因子已成共识。近年来,NO的非c GMP依赖调控机制——巯基亚硝基化修饰受到广泛关注。巯基亚硝基化属于蛋白质翻译后修饰,广泛参与调控生物体内各种生理病理过程。本综述将从NO相关的蛋白质巯基亚硝基化的发生和调控等方面简要介绍近年来相关工作的研究进展,并着重阐述巯基亚硝基化修饰在血管生理及相关疾病中发挥的调节作用。
[Abstract]:Nitric oxide (no) as an important vasodilator has become a consensus. In recent years, the non-c GMP dependent regulatory mechanism of nitric oxide (no), mercaptonitroso modification, has received wide attention. Mercaptonitrite is a post-translational modification of proteins and is widely involved in the regulation of various physiological and pathological processes in organisms. This review will briefly introduce the recent progress in the research on the occurrence and regulation of no related protein mercaptonitrite, and focus on the regulatory role of mercaptonitrite modification in vascular physiology and related diseases.
【作者单位】：北京大学基础医学院生理学与病理生理学系分子心血管学教育部重点实验室;
【基金】：supported by grants from the National Natural Science Foundation of China (No. 81370006, 91439206)
【分类号】：R54

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