中性粒细胞—淋巴细胞比值对急性主动脉夹层患者预后的预测价值

发布时间：2018-05-29 20:23

本文选题：急性主动脉夹层 + 中性粒细胞-淋巴细胞比值　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:探讨中性粒细胞-淋巴细胞比值(NLR)对急性A型主动脉夹层(AAD)患者的预后是否有预测价值。方法:采用病例-对照方法,观察新疆医科大学第一附属医院心内科住院诊治的急性A型主动脉夹层患者共106人,收集基本资料、实验室指标、治疗方案、随访情况等临床相关资料,根据ROC曲线得出NLR预测急性A型主动脉夹层患者死亡的最佳切点值,以此为分界点将患者分为低NLR组和高NLR组,采用SPSS 22.0软件进行统计学处理,分析NLR与急性A型主动脉夹层患者预后的关系。结果:106例患者中71例(67%)死亡,ROC曲线得出NLR预测急性A型主动脉夹层患者死亡的最佳切点值为4.88,其敏感度、特异度分别为69%和40%。并以Kaplan-Meier生存分析显示,高NLR组的死亡率明显大于低NLR组,危险因素的多因素Logistic回归分析后,NLR(4.88)是预测急性A型主动脉夹层患者死亡的独立危险因素(OR=3.70,95%CI:1.39—9.80,P=0.009)。结论:高NLR值是急性A型主动脉夹层患者死亡的独立危险因素,对其早期危险分层有一定的参考价值。
[Abstract]:Objective: to investigate the prognostic value of neutrophil-lymphocyte ratio (NLR) in patients with acute type A aortic dissection (AAD). Methods: a total of 106 patients with acute type A aortic dissection in Department of Cardiology, first affiliated Hospital of Xinjiang Medical University, were observed by case-control method. According to the ROC curve, the best cut point value of NLR to predict the death of acute type A aortic dissection patients was obtained. The patients were divided into low NLR group and high NLR group as the dividing point. The patients were treated with SPSS 22.0 software. To analyze the relationship between NLR and prognosis in patients with acute type A aortic dissection. Results the optimal point of NLR for predicting the death of patients with acute type A aortic dissection was 4.88, with sensitivity and specificity of 69% and 40%, respectively. Kaplan-Meier survival analysis showed that the mortality rate of high NLR group was significantly higher than that of low NLR group. The multivariate Logistic regression analysis of risk factors was an independent risk factor for predicting the death of patients with acute type A aortic dissection. Conclusion: high NLR value is an independent risk factor for death in patients with acute type A aortic dissection.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R543.1

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