Klotho蛋白与Frank征的相关性研究

发布时间：2018-05-30 22:42

本文选题：Frank征 + Klotho蛋白　；参考：《西安医学院》2017年硕士论文

【摘要】：目的:Frank征又名耳垂折痕征,已有临床研究表明其与动脉粥样硬化性心血管疾病的发生有一定的相关性,但发生机制不清;Klotho蛋白作为一种多功能蛋白参与动脉粥样硬化的发生进展已得到证实,而其是否与Frank征的出现相关尚不清楚。本文旨在探讨汉族人群中Frank征与血清中Klotho蛋白的关系,为更进一步认识Frank征发生机制及其与心血管疾病之间的关系提供理论依据。方法:顺序选取2015年10月—2016年10月在陕西省人民医院心血管内科住院的患者,年龄在35岁-70岁之间,均为汉族。按照有无Frank征分为两组,其中阳性组47例,阴性组53例,所有入组患者于住院次日清晨空腹采集静脉血。采用ELISA(酶联免疫标记法)检测血清klotho蛋白的浓度。采用统计学的单因素方差分析法来分析Frank征阴性组和阳性组对应的Klotho蛋白浓度值的差异。在此基础上,采用散点图以及相关系数分析法分析Frank征和Klotho蛋白浓度之间的相关性。结果:Frank征阳性组和Frank征阴性组的年龄分布(X~2=8.01,P=0.0050.01)、平均年龄(F=11.05、P=0.0010.01)之间有统计学差异,两组的高血压、糖尿病、冠状动脉粥样硬化性心脏病、复合疾病病史及性别之间均无统计学差异(P0.05)。Frank征阳性组Klotho蛋白浓度0.32,Frank征阴性组Klotho蛋白浓度0.63,两者差异显著(P0.01)。Klotho蛋白浓度和Frank征相关性系数为0.52,具有中度相关性。结论:Frank征阳性患者Klotho蛋白浓度降低,提示Klotho蛋白通过衰老过程在Frank征形成过程中发挥作用。Klotho蛋白与Frank征有一定相关性。
[Abstract]:Objective: the fraction Frank sign, also known as the ear lobe crease sign, has been shown to be associated with the occurrence of atherosclerotic cardiovascular disease. However, the pathogenesis of Klotho protein as a multifunctional protein involved in the development of atherosclerosis has been confirmed, and it is not clear whether it is related to the occurrence of Frank sign. The purpose of this study was to investigate the relationship between Frank sign and serum Klotho protein in Han population, and to provide a theoretical basis for further understanding the mechanism of Frank sign and its relationship with cardiovascular disease. Methods: the patients aged between 35 and 70 were selected from October 2015 to October 2016 in the Department of Cardiovascular Medicine of Shaanxi Provincial people's Hospital. The patients were divided into two groups according to Frank sign: positive group (47 cases) and negative group (53 cases). The concentration of serum klotho protein was detected by Elisa. Univariate analysis of variance was used to analyze the difference of Klotho protein concentration between Frank sign negative group and positive group. On this basis, the correlation between Frank sign and Klotho protein concentration was analyzed by scatter plot and correlation coefficient analysis. Results there was a significant difference in age distribution between the positive group with Frank sign and the group with negative Frank sign (P < 0.01). There was a significant difference between the two groups in terms of age distribution (mean age was 11.05%, P < 0.0010.01), hypertension, diabetes mellitus, coronary atherosclerotic heart disease were found in the two groups. There was no significant difference in the history of complex diseases and sex. There was no significant difference in the concentration of Klotho protein between the patients with positive P0.05 and Frank sign 0.32 and the Klotho protein concentration of 0.63 in the negative group of Frank sign. The correlation coefficient between the two groups was 0.52, and the correlation coefficient between the two groups was 0.52, with moderate correlation. Conclusion the decreased concentration of Klotho protein in the positive patients with% Frank sign suggests that Klotho protein plays a role in the formation of Frank sign through senescence. Klotho protein is correlated with Frank sign.
【学位授予单位】：西安医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R54

【参考文献】