急性心肌梗死患者介入治疗术中无复流现象与生长分化因子15的相关性

发布时间：2018-05-31 02:02

本文选题：急性心肌梗死 + 经皮冠状动脉介入治疗　；参考：《中国动脉硬化杂志》2017年06期

【摘要】：目的观察经皮冠状动脉介入治疗术中出现无复流现象的急性心肌梗死(AMI)患者生长分化因子15(GDF-15)的表达水平,探讨其对无复流现象的预测价值。方法连续入选南京医科大学附属常州市第二人民医院心血管内科住院的急性心肌梗死患者共243例,入院后24 h内抽血测定GDF-15浓度,并根据介入手术中是否出现无复流现象分为无复流组与血流正常组,比较两组GDF-15表达水平的差异,评估GDF-15对无复流现象的预测价值。结果无复流组44例,平均年龄67.00±13.04岁,血流正常组(对照组)199例,平均年龄65.54±12.98岁。无复流组患者GDF-15浓度高于血流正常组患者(1073.43±364.38 ng/L比714.10±340.98 ng/L,P0.001)。GDF-15预测无复流现象的受试者工作特征曲线下面积(AUC)为0.829,95%CI为0.766~0.892。多因素回归分析提示GDF-15(OR:1.003,95%CI:1.001~1.004,P0.001)和女性(OR:2.996,95%CI:1.358~6.610,P=0.007)是无复流现象的独立危险因素。结论 GDF-15和女性是急性心肌梗死患者介入治疗中无复流现象的独立危险因素。
[Abstract]:Objective to investigate the expression of growth differentiation factor 15 (GDF-15) in patients with acute myocardial infarction (AMI) without reflow during percutaneous coronary intervention (PCI), and to explore the predictive value of GDF-15 in patients with acute myocardial infarction (AMI) without reflow during percutaneous coronary intervention (PCI). Methods A total of 243 consecutive inpatients with acute myocardial infarction were enrolled in the Department of Cardiovascular Medicine of the second people's Hospital of Changzhou affiliated to Nanjing Medical University. The concentration of GDF-15 was measured within 24 hours after admission. According to whether there was no reflow in interventional surgery, the patients were divided into two groups: no reflow group and normal blood flow group. The difference of GDF-15 expression between the two groups was compared, and the predictive value of GDF-15 for no-reflow phenomenon was evaluated. Results 44 cases (mean age 67.00 卤13.04 years) in non-reflow group and 199 cases (average age 65.54 卤12.98 years) in control group. The GDF-15 concentration in non-reflow group was higher than that in normal blood flow group (1073.43 卤364.38 ng/L vs 714.10 卤340.98 ng 路L ~ (-1) P _ (0.001) P _ (0.001N) 路GDF-15). The area under the operating characteristic curve was 0.829 ~ (95) CI = 0.766 ~ (0.892). Multivariate regression analysis showed that GDF-15 OR: 1.003 and 95% CI: 1.001 + 1.004 (P0.001) and female OR: 2.996 / 95CI: 1.3586.610P0.007) were independent risk factors for no reflow. Conclusion GDF-15 and women are independent risk factors for no reflow in patients with acute myocardial infarction.
【作者单位】：南京医科大学附属常州市第二人民医院心内科;
【分类号】：R542.22

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