血压变异性与缺血性脑白质高信号的相关性

发布时间：2018-05-31 13:16

本文选题：脑白质疏松 + 脑白质高信号　；参考：《山东医药》2017年17期

【摘要】：目的探讨血压变异性与缺血性脑白质高信号(IWMH)的相关性。方法选取573例住院查体者,根据头部核磁共振对IWMH按照Fazekas评分标准进行严重程度评估分为无或轻度IWMH组284例(总体评分2分),中度IWMH组156例(总体评分2~4分),重度IWMH组133例(总体评分4分)。采用动态血压监护仪检测三组24 h收缩压、24 h舒张压、白天收缩压、白天舒张压、夜间收缩压、夜间舒张压及相应血压变异系数(BPV)。采用多项Logistic回归分析血压变异性与IWMH的关系。结果无或轻度IWMH、中度IWMH、重度IWMH组24 h收缩压、白天收缩压、夜间收缩压、收缩压BPV、舒张压BPV依次升高,三组比较差异有统计学意义(P均0.05)。多项logistic回归分析校正混杂因素后,收缩压及其BPV升高是IWMH的独立危险因素(P均㩳0.05)。结论收缩压和血压变异性增高与IWMH独立相关。
[Abstract]:Objective to investigate the correlation between blood pressure variability and ischemic brain white matter hypersignal (IWMH). Methods 573 hospitalized patients were selected to be divided into 284 cases of no or mild IWMH group (total score 2), 156 cases in middle degree IWMH group (total score 2~4), and 133 cases of severe IWMH group, according to head MRI on Fazekas score standard. (total score of 4). The ambulatory blood pressure monitor was used to detect three groups of 24 h systolic pressure, 24 h diastolic pressure, daytime systolic pressure, daytime diastolic pressure, night systolic pressure, night diastolic pressure and corresponding blood pressure variation coefficient (BPV). Multiple Logistic regression was used to analyze the relationship between blood pressure variability and IWMH. The results were no or mild IWMH, moderate IWMH, and severe IWMH group 24 h Systolic pressure, daytime systolic pressure, night systolic pressure, systolic pressure BPV, and diastolic pressure BPV increased in turn. The three groups were statistically significant (P 0.05). After multiple logistic regression analysis correction of confounding factors, systolic pressure and BPV elevation were independent risk factors of IWMH (P? 0.05). Conclusion systolic pressure and high blood pressure variability are related to IWMH independent.
【作者单位】：首都医科大学附属北京朝阳医院;
【基金】：国家自然科学基金项目(81271309)
【分类号】：R544.1;R741

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