特发性肺动脉高压患者血清高迁移率族蛋白B1水平及其临床意义

发布时间：2018-05-31 23:01

本文选题：特发性肺动脉高压 + 高迁移率族蛋白B　；参考：《中山大学学报(医学科学版)》2017年06期

【摘要】：【目的】探讨血清高迁移率组蛋白B1(HMGB1)作为特发性肺动脉高压(IPAH)患者生物标志物的可行性及临床价值。【方法】收集2011年5月至2015年4月中南大学湘雅二医院住院及门诊的IPAH患者33例,并对8例使用肺动脉高压靶向药物治疗的IPAH患者随访6个月。采用酶联免疫法(ELISA)测定血清HMGB1浓度。【结果】IPAH患者血清HMGB1水平(ng/m L)显著高于健康成人对照组(14.8±2.4 vs.3.8±1.2,P0.001)。IPAH患者血清HMGB1水平与平均肺动脉压力、肺血管阻力呈显著正相关(r=0.460,P=0.002;r=0.541,P=0.001)。8例IPAH患者使用肺动脉高压靶向药物治疗6月后,在肺动脉压力(mm Hg,62.3±9.7 vs.54.0±8.7,P0.001)和6 min步行试验(m)得到改善的同时(368±69 vs 401±55,P0.001),血清HMGB1水平(ng/m L)显著降低(15.9±5.3 vs.11.1±2.5,P=0.021)。【结论】检测血清HMGB1水平可在一定程度上反映肺动脉高压靶向药物的治疗效果,有望成为IPAH患者重要的随访指标。
[Abstract]:[objective] to investigate the feasibility and clinical value of high mobility histone B1HMGB1 as a biomarker in patients with idiopathic pulmonary hypertension (IPAH). [methods] from May 2011 to April 2015, Xiangya No.2 Hospital, Central South University, was collected. And 33 outpatients with IPAH, Eight IPAH patients with pulmonary hypertension were followed up for 6 months. Serum HMGB1 concentration was measured by Elisa. [results] the serum HMGB1 level in IPAH patients was significantly higher than that in healthy adults (14.8 卤2.4 vs.3.8 卤1.2 P 0.001N 路IPAH), and the mean pulmonary artery pressure and serum HMGB1 level in IPAH patients were significantly higher than those in healthy adults. Pulmonary vascular resistance was significantly correlated with pulmonary vascular resistance in patients with pulmonary hypertension (IPAH). At the same time of improvement of pulmonary artery pressure (62.3 卤9.7 vs.54.0 卤8.7 P0.001) and 6 min walking test, 368 卤69 vs 401 卤55 P0.001g / mL, serum HMGB1 level decreased significantly (15.9 卤5.3 vs.11.1 卤2.5 P0.021). [conclusion] Detection of serum HMGB1 level can reflect the therapeutic effect of targeted drugs on pulmonary hypertension to some extent. It is expected to be an important follow-up index for IPAH patients.
【作者单位】：中南大学湘雅二医院心内科;南方医科大学附属第三医院心内科;
【基金】：国家自然科学基金(81370249,81600249) 湖南省自然科学基金(2017JJ3455)
【分类号】：R544.1

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