非瓣膜性房颤患者华法林用药依从性及其影响因素的调查分析

发布时间：2018-06-01 23:25

本文选题：非瓣膜性房颤 + 华法林　；参考：《中国药房》2017年27期

【摘要】：目的:为改善非瓣膜性房颤患者用药依从性,更好地保证治疗安全性和有效性提供参考。方法:选取部分在我院住院接受华法林抗凝治疗的非瓣膜性房颤患者进行问卷调查,分别采用8条目Morisky用药依从性量表(MMAS-8)和华法林用药知识量表(WRKS)评估患者华法林用药依从性及抗凝治疗相关知识知晓情况,并应用χ2检验、t检验及Logistic多元回归分析方法探讨影响患者华法林用药依从性的相关因素。结果:共发放问卷129份,回收有效问卷112份,有效回收率为86.82%。受访患者MMAS-8平均得分为(6.54±1.61)分,用药依从性好者占42.86%。受访患者WRKS平均得分为(7.95±1.65)分,用药依从性好者平均得分为(9.31±0.83)分,用药依从性差者平均得分为(6.92±1.34)分。单因素分析发现,用药依从性好者与用药依从性差者在性别、年龄、职业、文化程度、合并症种数、WRKS得分等方面比较,差异均有统计学意义(P0.05)。Logistic多元回归分析结果显示,WRKS得分、性别、文化程度、合并症种数与受访患者用药依从性均显著相关(P0.05)。结论:非瓣膜性房颤患者华法林用药依从性较差,与多种影响因素相关,其中华法林抗凝治疗相关知识知晓情况是一个重要因素。
[Abstract]:Objective: to improve the compliance of patients with non-valvular atrial fibrillation and to ensure the safety and efficacy of the treatment. Methods: some non-valvular atrial fibrillation patients who received warfarin anticoagulant therapy in our hospital were investigated by questionnaire. Morisky compliance scale (MMAS-8) and warfarin drug knowledge scale (WRKS) were used to evaluate warfarin compliance and knowledge of anticoagulant therapy. 蠂 2 test and Logistic multiple regression analysis were used to study the factors influencing the compliance of warfarin. Results: 129 questionnaires were sent out, 112 valid questionnaires were collected, and the effective recovery rate was 86.82. The average score of MMAS-8 was 6.54 卤1.61, and 42.86 had good compliance. The average score of WRKS was 7.95 卤1.65, the average score of patients with good compliance was 9.31 卤0.83), the average score of patients with poor compliance was 6.92 卤1.34. Univariate analysis showed that there were significant differences in sex, age, occupation, education level and WRKS score between the patients with good compliance and those with poor compliance. The results of multiple logistic regression analysis showed that the scores of WRKS were significant. Sex, education level and the number of patients with complications were significantly correlated with drug compliance (P 0.05). Conclusion: warfarin compliance in patients with non-valvular atrial fibrillation is poor, which is related to many factors, among which warfarin anticoagulant therapy knowledge is an important factor.
【作者单位】：泰山医学院附属医院药剂科;泰山医学院附属医院心内科;
【基金】：泰山医学院附属医院青年科学基金计划项目(No.2014QN05)
【分类号】：R541.75

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