老年高血压患者中心动脉压与肾功能的相关性

发布时间：2018-06-02 23:41

本文选题：高血压 + 中心动脉血压　；参考：《中国老年学杂志》2017年14期

【摘要】：目的探讨老年高血压患者中心动脉压(CAP)与肾功能的相关性。方法年龄≥60岁高血压患者250例,患者按年龄分为4组(60~69岁,70~79岁,80~89岁,≥90岁);分别测量外周动脉血压(PAP)、肾功能、血脂、体重指数(BMI)等指标;采用中国人矫正的MDRD公式计算肾小球滤过率(GFR);通过HEM-9000AI脉波检测装置测量CAP[包括中心动脉收缩压(CSBP)、中心动脉压(CPP)、增强压(AP)、反射波增强指数(AIx)];将GFR与危险因素进行多元线性回归分析。结果肌酐、GFR、脉压(PP)随年龄增大而增高(P0.05);年龄、CSBP、AP、Alx、肌酐与GFR呈负相关(β=-0.105、-0.162、-0.294、-0.972、-0.887,P0.01)。结论 MAP呈增龄性改变,随年龄的增长而增加;在PAP降低相同的情况下,MAP越高,在一定程度上提示肾功能损害越严重。
[Abstract]:Objective to investigate the correlation between central arterial pressure (CAP) and renal function in elderly patients with hypertension. Methods 250 patients with hypertension aged more than 60 years were divided into 4 groups according to their age. The peripheral arterial blood pressure (PAPP), renal function, blood lipids and body mass index (BMIs) were measured respectively. Using the MDRD formula corrected by the Chinese to calculate the glomerular filtration rate (GFR); using the HEM-9000AI pulse wave detection device to measure CAP [including central arterial systolic pressure (CPP), central arterial pressure (CPP), enhanced pressure (APP), reflection wave enhancement index (AIX)]; and carrying out multiple measures of GFR and risk factors. Meta-linear regression analysis. Results the creatinine GFR (PP) increased with age (P 0.05), and the age of GFR was negatively correlated with GFR (尾 -0.105) (尾 -0.105- 0.162- 0.294- 0.972U -0.887g) (P 0.01). Conclusion the changes of MAP are age-related and increase with the increase of age, and the higher the map of PAP is, the more serious the damage of renal function is to a certain extent.
【作者单位】：四川省医学科学院四川省人民医院老年心内科;
【分类号】：R544.1

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