循环内皮细胞对冠心病心血管事件的预测价值

发布时间：2018-06-03 07:09

本文选题：循环内皮细胞 + 心血管事件　；参考：《安徽医科大学学报》2017年08期

【摘要】：目的探讨循环内皮细胞(CEC)计数成为急性冠脉综合征(ACS)患者心血管风险预测的重要生物标志的有效性。方法研究分析了110例ACS患者和30例健康人群作对照(HC组);根据其病史、症状、心电图、各种生化结果 ,利用两种不同的冠心病风险评分系统评估ACS患者的心血管事件风险:心肌梗死溶栓治疗临床试验(TIMI)评分评价非ST段抬高型心肌梗死(NSTEMI)/不稳定型心绞痛(UA)以及ST段抬高型心肌梗死(STEMI);全球急性冠状动脉事件注册(GRACE)评分评价所有冠心病;利用流式细胞仪检测静脉血CEC数。结果与HC组比较,ACS患者组的CEC计数明显升高,并随疾病的严重程度进行性升高;CEC计数和心血管事件风险的高低明显相关,TIMI UA/NSTEMI、TIMI/STEMI、GRACE评分相关系数分别为0.47、0.64、0.61(P0.05);CEC诊断急性心肌梗死中度可靠,受试者工作特征曲线下面积(AUC)=0.90(95%CI:0.84~0.94,P0.01);CEC计数诊断ACS中度可信,AUC=0.89(95%CI:0.82~0.93,P0.01)。结论 CEC计数的升高和ACS患者心血管事件的高风险密切相关,CEC可能成为心血管事件的有效预测因子。
[Abstract]:Objective to investigate the effectiveness of circulating endothelial cell count (CECcount) as an important biomarker for predicting cardiovascular risk in patients with acute coronary syndrome (ACS). Methods 110 patients with ACS and 30 healthy controls were studied and analyzed according to their history, symptoms, electrocardiogram and biochemical results. Evaluation of cardiovascular event risk in patients with ACS using two different coronary heart disease risk scoring systems: clinical trial of thrombolytic therapy for myocardial infarction (TIMII) for non-ST-segment elevation myocardial infarction / unstable angina pectoris (UAA) and St segment assessment. All coronary heart disease was evaluated by global acute coronary event registration (GRACEE) score. The number of CEC in venous blood was measured by flow cytometry. Results compared with the HC group, the CEC count in the patients with ACS increased significantly, and the correlation coefficient of TIMI / NSTEMIM / TMI / STEMIGRACE score with the severity of the disease was 0.47 / 0.640.64 / 0. 61P 0.05CEC was significantly correlated with the level of TIMI / NSTEMIM / TMI / TMI / TMI / GRACE score, respectively, in the diagnosis of acute myocardial infarction (AMI) with moderate reliability (P 0.05CEC). The area under the operating characteristic curve of subjects was 0.90 ~ 95% CI: 0.84 ~ 0.94 ~ 0.94 ~ 0.01 CEC count for the diagnosis of moderate confidence of ACS and 0.8995% CI: 0.82 ~ 0.93C ~ (0.01) ~ (-1) for the diagnosis of ACS. Conclusion the increase of CEC count and the high risk of cardiovascular events in ACS patients may be effective predictors of cardiovascular events.
【作者单位】：贵州医科大学附属医院心血管内科;贵州医科大学附属医院超声中心;贵州医科大学附属医院血液科;第二军医大学防化教研室;
【基金】：国家留学基金委(编号:201308525105) 贵州医科大学附属医院博士基金资助(编号:C-2012-3)
【分类号】：R541.4

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