血清尿酸与高血压左心室肥厚的相关性及性别差异

发布时间：2018-06-03 23:00

  本文选题：血清尿酸 + 原发性高血压　； 参考：《中华高血压杂志》2017年06期

【摘要】：目的探讨血清尿酸与高血压患者左心室肥厚(LVH)的关系,以及这种关系在男女之间是否存在差异。方法选择福建省级机关医院原发性高血压患者2140例,根据血清尿酸水平四分位数分组,比较4组的左心室质量指数(LVMI)和左心室肥厚(LVH)发生率;按男、女分层,比较男、女尿酸四分位组间LVMI和LVH发生率的差异;采用多因素Logistic回归分析男、女患者尿酸与LVH发生的关系。结果随着尿酸四分位水平递增,女性患者LVMI和LVH发生率逐渐增加[分别为(114.41±34.51),(121.34±36.98),(126.86±42.52),(141.74±46.36)g/m2;35.0%,47.0%,52.1%,61.7%;均P0.05],而男性患者4组间LVMI差异有统计学意义[分别为(144.12±76.44),(132.58±40.39),(134.24±41.00),(141.84±55.02)g/m2;P0.05],LVH发生率差异无统计学意义(57.1%,50.2%,54.3%,52.7%;P0.05)。和女性相比,男性尿酸、LVMI升高,LVH发生率增加(均P0.05)。Logistic回归分析显示,尿酸是女性患者中LVH发生的独立危险因素[OR(95%CI)=1.30(1.13~1.56),P0.01],男性患者中尿酸与LVH的相关性无统计学意义(P0.05)。结论尽管女性高血压患者尿酸及LVH程度较男性低,但女性患者尿酸与LVH相关,而男性患者这种相关性无统计学意义。
[Abstract]:Objective To investigate the relationship between serum uric acid and left ventricular hypertrophy ( LVMI ) in patients with hypertension , and whether there was any difference between men and women . The incidence of LVMI and LVMI in male and female patients was significantly increased according to serum uric acid level . Results The incidence of LVMI in female patients was significantly higher than that in male and female patients ( 144.12 卤 76.44 ) , ( 132.58 卤 40.39 ) , ( 134.24 卤 41.00 ) , ( 144.84 卤 55.02 ) g / m2 , P0.05 and P0.05 ) . Logistic regression analysis showed that uric acid was the independent risk factor ( OR ( 95 % CI ) = 1.30 ( 1.13 锝，

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