超敏C反应蛋白和脑钠肽及脂联素水平与冠心病患者相关性

发布时间：2018-06-04 01:28

本文选题：超敏C反应蛋白 + 脑钠肽　；参考：《中国临床药理学杂志》2017年05期

【摘要】：目的探讨超敏C反应蛋白(hs-CRP)、脑钠肽(BNP)、脂联素(APN)水平的变化对冠心病发生、发展及预后的影响。方法将528例受试者分为对照组(同时期健康的体检者)250例和试验组(冠心病患者)278例,并将试验组根据冠心病的临床类型分为急性心肌梗死(AMI)组40例、不稳定型心绞痛(UPA)121例、稳定型心绞痛患者(SAP)组117例。用胶乳免疫比浊法检测2组患者血清中的hs-CRP含量;用化学免疫发光微粒子检测试验组患者血清中的BNP的含量;用酶联免疫法分别测定试验组患者血清中的APN的含量。结果对照组和试验组血清hs-CRP分别为(3.78±2.12),(7.29±5.98)mg·L~(-1),差异有统计学意义(P0.05),血清APN含量分比为(81.21±20.89),(1423.89±1389.21)pg·m L~(-1),差异有统计学意义(P0.05);血清BNP水平分别为(929.23±312.67),(412.34±299.89)μg·m L~(-1),差异有统计学意义(P0.05)。在冠心病试验组中,hs-CRP浓度与BNP水平无相关性,差异无统计学意义(P0.05);hs-CRP与APN呈负相关(r=-0.567),差异有统计学意义(P0.05);BNP和APN无相关性,差异无统计学意义(P0.05)。结论冠心病患者血清hs-CRP、血清APN和血清BNP水平的变化程度与冠心病的发展程度有着密切的联系,是冠心病发生的危险因素。
[Abstract]:Objective to investigate the effect of the changes of the levels of the hypersensitive C-reactive protein (hs-CRP), brain natriuretic peptide (BNPN) and adiponectin (APN) on the occurrence, development and prognosis of coronary heart disease (CHD). Methods 528 subjects were divided into two groups: the control group (250 healthy persons at the same time) and the experimental group (278 patients with coronary heart disease). According to the clinical type of coronary heart disease, the experimental group was divided into acute myocardial infarction group (40 cases) and unstable angina pectoris group (121 cases). There were 117 patients with stable angina pectoris (SAP) group. The content of hs-CRP in serum of two groups was detected by latex immunoturbidimetry, the content of BNP in serum of test group was detected by chemiluminescent microparticles, and the content of APN in serum of test group was determined by enzyme linked immunosorbent assay (Elisa). Results the serum hs-CRP of the control group and the experimental group were 3.78 卤2.12 卤5.98)mg L ~ (-1), the difference was statistically significant (P 0.05), the ratio of serum APN content was 81.21 卤20.89 卤1389.21)pg ~ (-1), the difference was significant (P0.05), and the serum BNP level was 929.23 卤312.67 (412.34 卤299.89) 渭 g / mL ~ (-1). There was no correlation between the concentration of hs-CRP and the level of BNP in coronary heart disease test group. There was no significant difference between hs-CRP and APN. There was no correlation between hs-CRP and APN, but there was no correlation between APN and P0.05. There was no significant difference between hs-CRP and APN. Conclusion the changes of serum hs-CRP, serum APN and serum BNP levels in patients with coronary heart disease are closely related to the development of coronary heart disease and are risk factors of coronary heart disease.
【作者单位】：泉州市第一医院老年病科;泉州市第一医院老年全科医学科;福建医科大学附属第一医院心内科;
【基金】：福建省卫生系统中青年骨干人才培养项目资助计划(2013-ZQN-ZD-18)
【分类号】：R541.4

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