重组质粒肝细胞生长因子在下肢缺血性疾病中的应用

发布时间：2018-06-04 14:40

本文选题：下肢缺血性疾病 + 重组质粒肝细胞生长因子　；参考：《重庆医科大学》2017年硕士论文

【摘要】：目的通过多中心、随机、双盲、多剂量(包括安慰剂)平行对照的临床试验探索重组质粒肝细胞生长因子注射液治疗下肢缺血性疾病的有效性与安全性。方法选择初筛合格的患者作为下肢缺血性疾病的研究的病例模型(本次均选择慢性下肢动脉缺血性疾病伴溃疡形成病例,有利于临床观察),对患肢沿胫前、胫后动脉走形选择32点注射(共注射三次D0、D14、D28),并对每个注射病例进行临床随访观察6个月,了解缺血性溃疡愈合情况、踝肱指数(ABI)及经皮氧分压(Tc PO2)变化情况。结果注射重组质粒肝细胞生长因子随机、双盲临床实验所选临床8例受试者中7例下肢血供明显改善,溃疡愈合或溃疡面积明显缩小。溃疡面积总体呈逐渐减小进而愈合趋势。结论重组质粒肝细胞生长因子通过促进下肢动脉毛细血管再生,从而改善缺血区域血供并促进溃疡的愈合。重组质粒-肝细胞生长因子治疗下肢缺血性疾病是一种安全且有效的方法。
[Abstract]:Objective to investigate the efficacy and safety of recombinant plasmid hepatocyte growth factor injection in the treatment of ischemic disease of lower extremity by multicenter, randomized, double-blind, multi-dose (including placebo) parallel controlled clinical trials. Methods the eligible patients were selected as the case model for the study of ischemic disease of lower extremity (all of them were selected as cases of chronic arterial ischemic disease of lower extremity with ulceration, which was beneficial to clinical observation and to the anterior tibia of the affected limb. The posterior tibial artery was injected at 32 points (three times D0 D14 D28), and each case was followed up for 6 months to find out the healing of ischemic ulcer, ankle brachial index (ABI) and percutaneous partial pressure of oxygen (TcPO2). Results the blood supply of lower extremity was improved significantly in 7 of 8 subjects who were randomly injected with recombinant plasmid hepatocyte growth factor, and the ulcer healing or ulcer area was reduced obviously. The ulcer area decreased gradually and then healed. Conclusion the recombinant plasmid hepatocyte growth factor can improve the blood supply of ischemic region and promote the healing of ulcer by promoting the regeneration of lower extremity artery capillary. The recombinant plasmids-hepatocyte growth factor (HGF) is a safe and effective method for the treatment of ischemic diseases of lower extremities.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R543

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