血清中肝素结合表皮生长因子、磷酸二酯酶4D的水平与急性冠状动脉综合征的关系

发布时间：2018-06-05 02:45

本文选题：肝素结合表皮生长因子 + 磷酸二酯酶D　；参考：《中国动脉硬化杂志》2017年11期

【摘要】：目的探讨血清中肝素结合表皮生长因子(HB-EGF)、磷酸二酯酶4D(PDE4D)的水平与急性冠状动脉综合征的关系。方法采用双抗体夹心ABC-ELISA法检测50例急性冠状动脉综合征患者(ACS组)及100例正常对照者(对照组)的HB-EGF蛋白及PDE4D蛋白的血清水平,运用Logistic回归分析评估它们与ACS的关系。结果校正高血压、吸烟、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDLC)、体质指数(BMI)等单因素分析有意义的因素后,发现HB-EGF蛋白水平与是否罹患ACS有关[OR=4.114,95%CI为(1.782,9.498),P=0.001];PDE4D蛋白水平也与是否罹患ACS有关[OR=5.049,95%CI为(1.764,14.448),P=0.003]。结论血清中HB-EGF、PDE4D水平与是否罹患急性冠状动脉综合征有关,HB-EGF、PDE4D水平高者患急性冠状动脉综合征的风险高。
[Abstract]:Objective to investigate the relationship between serum heparin binding epidermal growth factor (EGF) HB-EGFN, phosphodiesterase (PDP) and acute coronary syndrome (ACS). Methods the serum levels of HB-EGF protein and PDE4D protein in 50 patients with acute coronary syndrome (ACS) and 100 normal controls (control group) were detected by double antibody sandwich ABC-ELISA method. The relationship between HB-EGF protein and ACS was evaluated by Logistic regression analysis. Results after univariate analysis, such as hypertension, smoking, triglyceride TGG, total cholesterol TCU, low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol (HDLC), body mass index (BMI), and so on, It was found that the level of HB-EGF protein was related to the presence of ACS [OR 4.114 ~ 95 CI = 1.782 / 9.498P0. 001] the level of PDE4D protein was also correlated with ACS [OR5. 049 / 95 CI = 1. 764 卤14. 448 P0. 003]. Conclusion the patients with high HB-EGFG PDE4D levels associated with acute coronary syndrome are at high risk of acute coronary syndrome.
【作者单位】：郑州大学附属郑州中心医院转化医学中心;郑州大学附属郑州中心医院心血管内科四病区;
【分类号】：R541.4

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