参芪扶正注射液对慢性心衰急性加重患者的临床疗效研究

发布时间：2018-06-05 05:27

  本文选题：参芪扶正注射液 + 慢性心力衰竭　； 参考：《蚌埠医学院》2017年硕士论文

【摘要】：目的:观察治疗组与对照组治疗前后的心功能疗效、NT-proBNP、左心室射血分数、左心室舒张末期内径、同型半胱氨酸、超敏C反应蛋白与空腹血糖以及糖化血红蛋白水平的改变,来评价参芪扶正注射液对慢性心力衰竭合并2型糖尿病患者的心功能疗效以及对血糖水平的影响。方法:本研究收集了2015.5至2016.12期间在本院心内科、心内科重症监护室住院病人,且临床明确诊断为慢性心力衰竭合并2型糖尿病患者,中医证候分型为气虚血瘀型,共150例,严格按照入选标准与排除标准筛选后,运用随机数字表法随机分配到实验组和对照组,对照组采用持续低流量吸氧,基础疾病治疗,严格控制血糖,强心利尿剂,硝酸酯类血管紧张素Ⅱ受体拮抗剂(ARB),β受体阻断剂(β-Block),醛固酮受体拮抗剂及扩血管药物等治疗心力衰竭,均使用小剂量叶酸片口服,实验组在常规治疗基础上加予参芪扶正注射液(250ml)治疗,1次/天,治疗14天。结果:对照组与实验组治疗前后心功能、血糖水平、HCY、hs-CRP均有不同程度改善。在降低N-端脑利钠肽前体(NT-proBNP)水平上,实验组与对照组相比,差异具有统计学意义(P0.05);治疗后两组患者的左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、心功能疗效、超敏C反应蛋白(hs-CRP)差异具有统计学意义(P0.05);治疗后对照组与实验组同型半胱氨酸(HCY)水平未见明显差异(P0.05);在降低血糖方面,实验组与对照组患者的空腹血糖(FBG)差异具有统计学意义(P0.05);两组患者治疗前后糖化血红蛋白(HbA1c)水平未见明显差异(P0.05)。两组患者治疗中未出现明显不良反应,安全性较好。结论:参芪扶正注射液能有效改善慢性心力衰竭合并2型糖尿病患者的心功能指标,能降低hs-CRP水平,并能有效降低患者的血糖水平,在常规诊疗过程中加用参芪扶正注射液可以提高临床疗效,且无明显不良反应。
[Abstract]:Objective: to observe the changes of NT-proBNP, left ventricular ejection fraction, left ventricular end-diastolic diameter, homocysteine, hypersensitive C-reactive protein, fasting blood glucose and glycosylated hemoglobin in the treatment group and control group before and after treatment. To evaluate the effect of Shenqi Fuzheng injection on heart function and blood glucose level in patients with chronic heart failure and type 2 diabetes. Methods: during the period from 2015.5 to 2016.12, we collected the hospitalized patients in the Department of Cardiology and intensive Care Unit of the Department of Cardiology, and the patients with type 2 diabetes mellitus were definitely diagnosed as chronic heart failure, and the TCM syndromes were classified as qi deficiency and blood stasis, a total of 150 cases. After screening according to the selection criteria and exclusion criteria, the experimental group and the control group were randomly assigned to the experimental group and the control group. The control group was treated with continuous low flow oxygen inhalation, basic disease treatment, strict control of blood glucose, and diuretics. Low dose folic acid tablets were used to treat heart failure with nitrates angiotensin 鈪，

本文编号：1980767