非高血压中老年人群血压变化与颈动脉斑块的相关性

发布时间：2018-06-06 14:16

本文选题：颈动脉斑块 + 中老年　；参考：《中华高血压杂志》2017年02期

【摘要】：目的探讨开滦研究队列基线(2006年)血压水平及4年后(2010年)血压变化与颈动脉斑块检出率的关系。方法在参加2006-2007年度开滦集团健康体检的职工101 510人中分层随机抽取观察对象,按入选标准选取观察对象5440人组成研究队列,于2010-2011年对观察队列进行健康体检,并进行颈动脉超声检查。选取队列中非高血压人群共计3802人进行统计分析。根据基线血压和4年间血压变化进一步分为:(1)稳定为正常血压组(n=673);(2)正常血压进展为正常高值血压组(n=793);(3)正常血压进展为高血压组(n=408);(4)正常高值血压降为正常血压组(n=295);(5)稳定为正常高值血压组(n=915);(6)正常高值血压进展为高血压组(n=718),观察血压变化与颈动脉斑块的关系。结果正常血压人群颈动脉斑块的检出率为32.4%,正常高值血压人群颈动脉斑块的检出率为38.1%;正常血压稳定为正常血压、进展为正常高值血压组及进展为高血压组斑块的检出率分别为19.2%、32.5%、54.2%;正常高值血压降为正常血压组、稳定为正常高值血压组及进展为高血压组斑块的检出率分别为27.8%、34.4%、46.9%。调整其他危险因素后,与稳定为正常血压组比较,正常血压进展为高血压组、正常高值血压降为正常血压组、稳定为正常高值血压组和正常高值血压进展为高血压组发生颈动脉斑块的OR值(95%CI)分别为2.451(1.604~3.744)、1.513(1.019~2.247)、1.643(1.212~2.228)和2.268(1.643~3.123)。结论非高血压人群中,随着血压水平的升高,颈动脉斑块的检出率增加。血压稳定在正常水平动脉粥样硬化风险较低。
[Abstract]:Objective to investigate the relationship between blood pressure level and carotid plaque detection rate in Kailuan study cohort (2006) and 4 years later (2010). Methods 5440 subjects were selected randomly and stratified from 1010510 workers who took part in the physical examination of Kailuan Group in 2006-2007. The study cohort was composed of 5440 subjects according to the selected criteria, and the observation cohort was examined in 2010-2011. Carotid ultrasound was performed. A total of 3802 non-hypertensive people were selected for statistical analysis. According to the baseline blood pressure and the change of blood pressure in 4 years, we further divided the normal blood pressure into two groups: 1) normal blood pressure group (n = 673) normal blood pressure progression to normal high blood pressure group (n = 793) normal blood pressure progression to hypertension group (n ~ (408) normal blood pressure decreased to normal blood pressure group (n ~ (29) 5 ~ (5) Stable to normal high blood pressure group (n = 915) normal high blood pressure progression to hypertension group, the relationship between blood pressure change and carotid plaques was observed. Results the detection rate of carotid plaque in normal blood pressure group was 32.4m, and that in normal high blood pressure group was 38.1%, the normal blood pressure was stable to normal blood pressure. The detection rate of plaque in the group of progression to normal high blood pressure and the group of progression to hypertension were 19.2 and 32.5, respectively. The positive rates of plaque of normal high blood pressure decreased to normal blood pressure group, stable to normal high value blood pressure group and progression to hypertension group were 27.834.4% and 46.9%, respectively. After adjusting for other risk factors, compared with the stable normal blood pressure group, the normal blood pressure progressed to the hypertension group, and the normal high blood pressure decreased to the normal blood pressure group. The OR 95 (CI) of carotid artery plaque in hypertension group and normal high blood pressure group were 2.451U 1.604 ~ 3.744 ~ 1.5131.019 ~ 2.247N ~ (1.643) ~ 1.21212 ~ 2.228) and 2.268n ~ 1.6433.123.123 respectively. Conclusion the detection rate of carotid plaque increases with the increase of blood pressure in non-hypertensive population. Blood pressure stabilizes at normal levels and the risk of atherosclerosis is lower.
【作者单位】：上海市第六人民医院超声科;上海市嘉定区安亭医院麻醉科;开滦总医院肾内科;开滦总医院超声科;开滦总医院心内科;
【分类号】：R544.1

【相似文献】