慢性心力衰竭患者血清脂联素水平与心功能及左室重构的相关性

发布时间：2018-06-07 00:46

本文选题：慢性心力衰竭 + 脂联素　；参考：《中国老年学杂志》2017年01期

【摘要】：目的探究慢性心力衰竭(CHF)患者血清脂联素(APN)水平与心功能及左室重构的相关性。方法选择CHF患者112例及同期健康体检者30例为研究对象,采用酶联免疫吸附法(ELISA)测定血清APN水平,测量左室舒张末期内径(LVEDD)、左室后壁厚度(LVPWT)及室间隔厚度(IVST)、左心室质量(LVM)、左心室质量指数(LVMI)等心功能相关指标。采用纽约心脏病协会心功能分级标准(NYHA)对CHF患者心功能进行分级,分析血清APN水平与心功能及左室重构的相关性。结果随着患者心功能受损程度的增加,血清ANP逐渐升高(P=0.011);随着患者心功能受损程度的增加,ANP、LVEDd、IVST、LVPMT、LVM与LVMI水平均显著升高(P0.05)。CHF患者血清APN与LVEDd、IVST、LVPMT、LVM及LVMI均呈明显正相关(r=0.511,0.615,0.411,0.441,0.531;P0.05)。结论 CHF患者APN水平越高心功能越低,且与其水平与心脏左心室重塑呈正相关,可作为评价CHF患者心功能的一个重要指标。
[Abstract]:Objective to investigate the relationship between serum adiponectin (APN) level and cardiac function and left ventricular remodeling in patients with chronic heart failure (CHF). Methods Serum APN levels were measured by Elisa in 112 patients with CHF and 30 healthy controls at the same time. Left ventricular end-diastolic diameter (LVEDDN), left ventricular posterior wall thickness (LVPWT), interventricular septal thickness (IVSTT), left ventricular mass (LVM) and left ventricular mass index (LVMI) were measured. The New York Heart Association Cardiac function Classification Standard (NYHA) was used to grade the heart function of patients with CHF. The correlation between serum APN level and cardiac function and left ventricular remodeling was analyzed. Results with the increase of the degree of cardiac function impairment, the serum ANP increased gradually, and with the increase of the degree of cardiac function impairment, the levels of LVEDdT, LVPMTV, LVM and LVMI in patients with CHF were significantly higher than those in patients with P0.05. CHF. There was a significant positive correlation between serum APN and LVPMTLVM and LVMI in patients with CHF. Conclusion the higher the level of APN in CHF patients, the lower the cardiac function, and the positive correlation between APN level and left ventricular remodeling, which can be used as an important index to evaluate cardiac function in CHF patients.
【作者单位】：新疆医科大学第五附属医院心内科;
【分类号】：R541.6

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