高血压患者血清肝细胞生长因子的表达及与血管内皮功能的关系

发布时间：2018-06-07 17:21

本文选题：高血压 + 血清肝细胞生长因子　；参考：《中国老年学杂志》2017年09期

【摘要】：目的探讨高血压患者血清肝细胞生长因子(HGF)的表达及与血管内皮功能的关系。方法 60例高血压患者,按血压高低分级分为轻度组(n=21)、中度组(n=27)及重度组(n=12),另选取30例健康体检者作为对照组,比较各组受试者基线指标及HGF、血浆内皮素(ET)及血浆一氧化氮(NO)水平,同时分析HGF水平与ET及NO的相关性。结果各组受试者性别、年龄、空腹血糖(FBG)、甘油三酯(TG)比较差异无统计学意义(P0.05)。各组高血压患者血清HGF、ET及NO水平与对照组差异显著(P0.05);HGF及ET水平随血压的增高而增高,NO水平随血压的增高而下降,重度组各指标与轻度组及中度组差异显著(P0.05);轻度组与中度组HGF及NO水平差异显著(P0.05)。Spearman相关性分析显示,HGF与ET水平呈显著正相关(r=0.69,P0.05),HGF与NO水平呈显著负相关(r=-0.60,P0.05)。结论高血压患者血液中HGF的水平与血压水平及机体血管内皮功能受损程度具有显著相关性,可作为反映高血压患者内皮功能受损程度的一个新指标。
[Abstract]:Objective to investigate the expression of serum hepatocyte growth factor (HGF) and its relationship with vascular endothelial function in hypertensive patients. Methods 60 patients with hypertension were divided into mild group (n=21), moderate group (n=27) and severe group (n=12), and 30 healthy subjects were selected as control group. The baseline indexes and HGF, plasma levels of the subjects in each group were compared. The level of endothelin (ET) and plasma nitric oxide (NO), and the correlation between the level of HGF and ET and NO. Results there was no significant difference in the sex, age, fasting blood glucose (FBG) and triglyceride (TG) in the subjects of each group (P0.05). The serum HGF, ET and NO levels were significantly different from those in the control group (P0.05). The level of NO decreased with the increase of blood pressure, and the difference between the indexes of the severe group and the mild group and the moderate group was significant (P0.05). The difference of HGF and NO in the mild group and the moderate group was significant (P0.05).Spearman correlation analysis showed that there was a significant positive correlation between HGF and ET level (r= 0.69, P0.05), HGF was negatively correlated with NO level. The level of HGF in blood of hypertensive patients has a significant correlation with the level of blood pressure and the degree of vascular endothelial dysfunction, which can be used as a new index to reflect the degree of endothelial dysfunction in hypertensive patients.
【作者单位】：遵义市妇幼保健院内科;
【分类号】：R544.1

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