血清Galectin-3和脑钠肽在心脏再同步化治疗前后的变化及对近期预后的影响

发布时间：2018-06-10 20:57

本文选题：心脏再同步化治疗 + 半乳糖凝集素　；参考：《临床心血管病杂志》2017年01期

【摘要】：目的:分析我院行心脏再同步化治疗(CRT)前后心力衰竭(心衰)患者血清半乳糖凝集素3(Gal-3)、脑钠肽(BNP)水平变化及其对近期预后的影响。方法:对本院50例心衰患者的随访资料进行分析,随访时间12个月,根据患者是否接受CRT治疗分为CRT组及对照组,采用酶联免疫法(ELISA)检测治疗前及治疗后1、3、6、12个月血清Gal-3和BNP水平,并行超声心动图检查,评估心脏功能。结果:随访至12个月,CRT组和对照组Gal-3水平无明显变化,两组BNP水平均显著下降,且CRT组显著低于对照组(P0.05);CRT组左室舒张末容积(LVEDV)、左室收缩末容积(LVESV)均减小(P0.05),左室射血分数(LVEF)明显升高(P0.05);CRT组患者心衰再入院率显著低于对照组(分别为20%、52%,P=0.019),发生心脏不良事件再入院者基础Gal-3和BNP水平更高。结论:血清Gal-3在心衰患者治疗前后无明显变化,基础Gal-3和BNP水平高者近期预后较差。
[Abstract]:Objective: to analyze the changes of serum galactose agglutinin (Gal-3) and brain natriuretic peptide (BNP) levels in patients with heart failure (HF) before and after cardiac resynchronization therapy (CRT). Methods: 50 patients with heart failure were followed up for 12 months. The patients were divided into CRT group and control group according to whether they received CRT therapy or not. The serum levels of Gal-3 and BNP were measured by Elisa before and after treatment, and the cardiac function was evaluated by echocardiography. Results: there was no significant change in Gal-3 level in CRT group and control group after 12 months follow-up, but the BNP level in both groups decreased significantly. The left ventricular end-diastolic volume (LVEDVV) and left ventricular end-systolic volume (LVESVV) of CRT group were significantly lower than those of control group (P 0.05). The left ventricular ejection fraction (LVEF) was significantly higher in CRT group than that in control group (P 0.05). The readmission rate of heart failure in CRT group was significantly lower than that in control group (20 ~ 52i / P = 0.019, respectively). The basal Gal-3 and BNP levels were higher in patients with benign events readmission. Conclusion: serum Gal-3 does not change significantly before and after treatment in patients with CHF, and the prognosis of patients with high basal Gal-3 and BNP levels is poor in the near future.
【作者单位】：烟台毓璜顶医院心内科;
【基金】：烟台市科技发展计划项目(No:2013WS223)
【分类号】：R541.6

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